Volume No. :   1

Issue No. :  3

Year :  2011

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Antioxidant and Hepatoprotective Effects of the Methanol Extract of the Flowers of Tamarindus indica



Address:   Kanakam Vijayabhaskar1*, Goli Venkateshwarlu1, J. Bhaskar1, K. Srisailam2 and More Swapna3
1Venkateshwara Institute of Pharmaceutical Sciences, Nalgonda. 508002.
2Department of Pharmacy, Satavahana University, Karimnagar. 505001.
3Vaagdevi College of Pharmacy, Warangal. 506001.
*Corresponding Author
DOI No:

ABSTRACT:
A monotypic genus and belongs to the subfamily Caesalpinioideae of the family Leguminosae (Fabaceae), Tamarindus indica L., commonly known as Tamarind tree is one of the most important multipurpose tropical fruit tree species in the Indian subcontinent. antioxidative potential of the methanol extract of tamarindus indca was evaluated using various antioxidant assays, including DPPH, superoxide, nitric oxide (NO), hydroxyl radical scavenging and iron-chelating activity. Total phenolic and flavonoid content of SM was also determined by a colorimetric method. The extract exhibited powerful free radical scavenging, especially against DPPH, hydroxyl radical scavenging and iron-chelating activity as well as a moderate effect on NO and superoxide anions. The protective effects of methanol extract of SM were studied in carbon tetrachloride-reduced biochemical markers of hepatic injury such as glutamate pyruvate transaminase (SGPT), serum glutamate oxalaoacetate transaminase (SGOT), alkaline phosphatase (ALP), serum bilirubin, cholesterol alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. The increased level of HDL demonstrated dose dependant reduction in the in vivo peroxidation induced by CCl4. Degree of protection was measured by using biochemical parameters such as serum transaminase (GOT and GPT), alkaline phosphatase (ALKP) and bilirubin. Petroleum ether, Ethyl acetate and chloroform extracts did not show any effects. Results obtained in the present study suggest that Tamarindus indica elicits hepatoprotectivity through antioxidant activity on carbon tetrachloride- and paracetamol-induced hepatic damage in rats.
KEYWORDS:
Tamarindus indica hepatoprotective activity, antioxidant effect, biochemical parameters
Cite:
Kanakam Vijayabhaskar, Goli Venkateshwarlu, J. Bhaskar, K. Srisailam, More Swapna. Antioxidant and Hepatoprotective Effects of the Methanol Extract of the Flowers of Tamarindus indica. Asian J. Pharm. Tech. 1(3): July-Sept. 2011; Page 73-78.
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