Volume No. :   1

Issue No. :  4

Year :  2011

ISSN Print :  2231-5705

ISSN Online :  2231-5713


Registration

Allready Registrered
Click to Login

In Vitro Cytotoxic Study on Crude Extract of Marine Invertebrate Animal Polyclinum madrasensis Sebastian



Address:   Natarajan K.*, Ramanathan S., Sathish R. and C. Amudhadevi
Department of Pharmaceutical Biotechnology, Ultra College of Pharmacy, Madurai
*Corresponding Author
DOI No:

ABSTRACT:
Many marine origin organic molecules entered clinical studies for anticancer therapy. Ascidians, a marine invertebrate animal draw attention of the researchers for its versatility as medicine and nutrition. In this study methylene chloride crude extract of Polyclinum madrasensis Sebastian (Ascidaciae) was tested for its in-vitro anticancer property on HeLa cell lines (cervical cancer cell lines) using MTT assay. Results revealed that the extract exhibits cytotoxic effect on the cell lines used (IC 50- 0.23mg/ml). Extract was further elucidated using chemical and spectral analysis (IR, HNMR), in which peptides were found to be the major constituent. As a conclusion, Polyclinum madrasensis is found to be a good source for drug lead component in cancer drug discovery process.
KEYWORDS:
Polyclinum madrasensis, PME, Cytotoxicity, HeLa.
Cite:
Natarajan K., Ramanathan S., Sathish R. , C. Amudhadevi. In Vitro Cytotoxic Study on Crude Extract of Marine Invertebrate Animal Polyclinum madrasensis Sebastian. Asian J. Pharm. Tech. 1(4): Oct. - Dec. 2011; Page 152-154.
[View HTML]      [View PDF]



Visitor's No. :   15892