Volume No. :   2

Issue No. :  2

Year :  2012

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Synthesis, Characterization, Anti-tubercular, Analgesic and Anti-Inflammatory Activities of New 2- Pyrazoline Derivatives



Address:   Bindu Sree Koduru*, Akshay R. Shinde, P. Jaya Preeti, K. Pavan Kumar, R. Rajavel, T. Sivakumar
Department of Chemistry, Nandha College of Pharmacy and Research Institute, Erode-638052, Tamil Nadu, India.
*Corresponding Author
DOI No:

ABSTRACT:
The compounds of different Pyrazoline derivatives were synthesized by cyclization of substituted chalcone derivatives in presence of hydrazine hydrate (a-e). All the synthesized compounds were characterized by spectral analysis (IR, MS and NMR). The REMA (Resazurin Microtiter Assay) plate method was used for anti-tuberculosis activity. The minimum inhibitory concentration (MIC) of the newly synthesized compound was tested against Mycobacterium tuberculosis H37RV. The Analgesic activity was performed by Acetic acid induced method. The Anti-inflammatory activity was performed by Carrageenan induced paw edema method.
KEYWORDS:
Chalcone, Hydrazine Hydrate, Pyrazoline derivatives, Characterization, Anti-tuberculosis activity.
Cite:
Bindu Sree Koduru, Akshay R. Shinde, P. Jaya Preeti, K. Pavan Kumar, R. Rajavel, T. Sivakumar. Synthesis, Characterization, Anti-tubercular, Analgesic and Anti-Inflammatory Activities of New 2- Pyrazoline Derivatives. Asian J. Pharm. Tech. 2(2): April-June 2012; Page 47-50.
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