Volume No. :   2

Issue No. :  3

Year :  2012

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Formulation of fast dissolving tablets of Lisinopril using combination of synthetic superdisintegrants



Address:   Rajeshree Panigrahi1*, K.A. Chowdary2, Gitanjali Mishra3, Manas Bhowmik4, Saiprasanna Behera1
1Royal College of Pharmacy and Health Sciences - Berhampur
2St. Ann’s college of Pharmacy, Cantonment- Vizianagram
3Berhampur University- Berhampur
4Himalayan Institute of Pharmacy, Sikkim
*Corresponding Author
DOI No:

ABSTRACT:
Fast dissolving tablets of Lisinopril were designed using combination of synthetic superdisintegrants like croscarmellose sodium, crospovidone and sodium starch glycolate in a ratio of 5:10 and 10:5 respectively by direct compression method. The blends of all formulations were evaluated for various pre-formulation factors. Tablets were evaluated for weight variation, hardness, disintegration time, drug content, friability and in vitro dissolution. The formulation of Lisinopril containing 10% crospovidone and 5% croscarmellose showed disintegration time of 145±0.502 secs respectively with 99% drug release within 30 mins. The results showed that super disintegrants used in combinations shows better disintegrating property. The FTIR spectra showed no interactions among them.
KEYWORDS:
Fast Dissolving Tablet, Lisinopril, croscarmellose sodium, crospovidone, sodium starch glycolate
Cite:
Rajeshree Panigrahi, K.A. Chowdary, Gitanjali Mishra, Manas Bhowmik, Saiprasanna Behera. Formulation of fast dissolving tablets of Lisinopril using combination of synthetic superdisintegrants . Asian J. Pharm. Tech. 2(3): July-Sept. 2012; Page 94-98.
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