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Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
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Hepatoprotective activity of aerial part of Glinus oppositifolius L. against Paracetamol-induced Hepatic Injury in Rats.
S. K. Sahu
N. K. Tripathy
S. K. Sahu1*, D. Das2 and N. K. Tripathy1
1Department of Zoology, Berhampur University, Berhampur, Odisha –760007
2School of Pharmaceutical Sciences, SOA University, Bhubaneswar, Odisha-754030
Ethanolic extract (80%) aerial part of Glinus oppositifolius was prepared and tested for its hepatoprotective effect against paracetamol-induced hepatitis in rats. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP, cholesterol and bilirubin were tested in both treated and untreated groups. Paracetamol (2 g/kg) has enhanced the SGOT, SGPT, ALP, cholesterol and bilirubin levels. Treatment with ethanolic extract of aerial part of G. oppositifolius (200 mg/kg and 400 mg/kg) has reverse back the altered levels of biochemical markers to the near normal levels in the dose dependent manner.
Glinus oppositifolius; Hepatoprotective activity; Paracetamol; Silymarin.
S. K. Sahu, D. Das, N. K. Tripathy. Hepatoprotective activity of aerial part of Glinus oppositifolius L. against Paracetamol-induced Hepatic Injury in Rats. Asian J. Pharm. Tech. 2(4): Oct. - Dec. 2012; Page 154-156.
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