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Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
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Formulation of Clotrimazole vaginal suppository containing Lacto bacillus spores.
S.C. Shivhare1*, Dr. U.D.Shivhare2, Dr. Preeti Srivastav1, K.G. Malviya1
1MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur India.
2Sharad Pawar College of Pharmacy, Nagpur India.
Human vagina represents a dynamic ecosystem dominated by certain species of Lactobacillus. This microorganism restricts the growth of pathogens by using properties of steric exclusion and inhibitory substance production. Serious complications including bacterial vaginosis and vaginal cancer are often determined in women with reduced numbers of lactobacilli. Local application of Lactobacillus is consequently promising to keep the vagina colonized by this strain, which consequently reduces the infections. The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository containing lyophilized culture of Lactobacillus with anti microbial agent clotrimazole. The second objective was to establish a stable clotrimazole suppositiry alone with Lactic acid Bacillus Spores for vaginosis.
Vaginosis, Lactic acid Bacillus Spores, clotrimazole, formulation, viability, stability
S.C. Shivhare, U.D.Shivhare, Preeti Srivastav, K.G. Malviya. Formulation of Clotrimazole vaginal suppository containing Lacto bacillus spores. Asian J. Pharm. Tech. 3(1): Jan.-Mar. 2013; Page 05-08.
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