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Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
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Preparation and Evaluation of Solid Dispersion of Terbinafine Hydrochloride
Gampa Vijay Kumar
Subhashis Debnath1*, Gampa Vijay Kumar2, S.V. Satyanarayana3
1Seven Hills College of Pharmacy, Tirupati-517561, Andhra Pradesh, India.
2Vikas Institute of Pharmaceutical Sciences, Andhra Pradesh, India.
3Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India.
Terbinafine hydrochloride is a synthetic antifungal drug. It is slightly soluble in water (3mg/ml) and having high permeability through stomach. This results in poor bioavailability after oral administration. Therefore solid dispersion of terbinafine HCl with polyethylene glycol - 6000 (PEG 6000) and mannitol were prepared with a view to increase its water solubility. In this study solid dispersion of the drug were prepared by melting method and the drug was taken with carrier in the proportions of (1:1, 1:2 and 1:3). The rate of dissolution of terbinafine HCl was increased with the proportion of (1:3) (Drug : PEG 6000) when compared to the other formulations. In order to predict and correlate the release behavior of the drug from the polymer matrix the dissolution data were fitted in to a suitable model to describe the drug release behavior from polymeric system. The surface morphology of the prepared solid dispersion and drug alone were examined by SEM analysis. The SEM result shows that in the case of solid dispersion of terbinafine HCl, particles were in almost amorphous form, which indicates a reduction in particle size.
antifungal, bioavailability, solid dispersion, polymer matrix, SEM
Subhashis Debnath, Gampa Vijay Kumar, S.V. Satyanarayana. Preparation and Evaluation of Solid Dispersion of Terbinafine Hydrochloride. Asian J. Pharm. Tech. 3(1): Jan.-Mar. 2013; Page 09-15.
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