Volume No. :   3

Issue No. :  4

Year :  2013

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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In-Silico Analysis of Targeted Drug Delivery to Hepatic Cells using Lipid Nano-Particles to Treat Liver Diseases



Address:   Karthick J.1, Praveen Kumar P.K.2, SujathaLoganathan P.L.3
1Final Year, Department of Biotechnology, Sri Venkateswara College of Engineering, Sriperumbudur, Chennai.
2Assistant Professor, Department of Biotechnology, Sri Venkateswara College of Engineering, Sriperumbudur, Chennai
3Assistant Librarian, Department of Bioinformatics and ARIS Cell, Madras Veterinary College, Chennai
*Corresponding Author
DOI No:

ABSTRACT:
Liver diseases are the second most predominant diseases next to diabetes. Treatment of most of the liver diseases involves liver transplantation, which is not feasible due to lack of sufficient donors. Most of the drugs prescribed are random and doesn’t involve proper action in the patient. Hence targeted delivery of the drug is the most viable and affordable solution for treating liver diseases. Despite many available carriers like viral vectors, metallic vectors etc, liposomes are the most suitable drug carrier molecules and they are more advantageous than other materials. Targeted delivery experiments involve much tedious experimental procedures and complex biological pathway study. Developing and analysing these nano scale compounds are also much difficult and hence for the ease of work, tools of Bioinformatics are used to analyse and interpret the results. Hence in-Silico analysis are commonly used for analysing their pathway before carrying out the in-Vitro and in-Vivo experiments. This review article emphasis on the various procedures and software used in targeted delivery experiments.
KEYWORDS:
Drug Delivery, Liposomes, Nanoparticles, System Biology, Computational Biology.
Cite:
Karthick J., Praveen Kumar P.K., SujathaLoganathan P.L.. In-Silico Analysis of Targeted Drug Delivery to Hepatic Cells using Lipid Nano-Particles to Treat Liver Diseases. Asian J. Pharm. Tech. 2013; Vol. 3: Issue 4, Pg 189-194.
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