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Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
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Folate Mediated Drug Delivery using Nanoparticle
J. Madhusudhanan1*, S. Sandhya2 and S. Malathi2
1Associate Professor & Head, Department of Biotechnology, Shri Andal Alagar College of Engineering, Mamandur 603 111.
1, 2Final year, Department of Biotechnology, Shri Andal Alagar College of Engineering, Mamandur 603 111.
Many drugs are in the treatment of cancer, doxorubicin (DOX), a common cancer chemotherapeutics, was conjugated to folate-modified polyethyleneimine-functionalized gold nanoparticles. The controlled release behaviour of DOX-loaded gold nanoparticles was analysed using Tris HCl and PBS. The TEM and FTIR characterization says that there isa strong association of DOX over folate modified gold nanoparticle. DOX-loaded gold nanoparticles had higher cytotoxicity for folate-receptor-positive cells (KB cells) compared to folate-receptor-negative cells (A549 cells) which show lower cells viability at higher concentration of folate modified gold nanoparticle. The viability of KB cells is 7% and A549 cells are 17% at high concentration AuNP-PEI-FOL-DOX. The DOX effects on cancer cell DNA were determined by DNA cleavage pattern.
Nanoparticles, polymer, UV-VIS spectroscopy, TEM, Tryphan blue assay.
J. Madhusudhanan, S. Sandhya, S. Malathi. Folate Mediated Drug Delivery using Nanoparticle. Asian J. Pharm. Tech. 2013; Vol. 3: Issue 4, Pg 155-160.
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