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Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
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Formulation and Evaluation of Controlled Release Tablets of Antiepileptic Drugs
Narkhede Bhalchandra Gangadhar
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Narkhede Bhalchandra Gangadhar*
Institute of Pharmaceutical Science & Research centre, Bhagwant University, AJMER
Antiepileptic, moisture sensitive drug has been made to prepare a controlled release matrix tablet by Wet granulation method and applied a moisture barrier coating to prevent its degradation due to moisture. The combination of hydrophilic polymer such as Hydroxy propyl methyl cellulose and hydrophobic polymer such as Ethyl cellulose in the ratio of 10:1 can be utilized for designing and development of controlled release solid dosage form and It has been also evaluated coating of core tablet with Opadry violet followed by eudragit E100 with different ratio and wait gain weight gain of tabletfor the best coating materials for moisture protection and also compared with marketed product. The Batch contained HPMC 125 mg and ethyl cellulose 12 mg per tablet showed 94.8% drug release at the end of 18 hrs and F2 value was 79.28. So it showed more comparable dissolution profile with respect to marketed product. When it coated with Opadry violet (4%) followed by Eudragit E100 coating (4%) was observed to remain intact after 6 days. The developed controlled release table of antiepileptic drug was found to be equivalent with regard to dissolution profile with marketed product and shows promising moisture protecting Barrier for moisture sensitive antiepileptic drug.
Antiepileptic drug, moisture protecting, controlled release, wet granulation.
Narkhede Bhalchandra Gangadhar. Formulation and Evaluation of Controlled Release Tablets of Antiepileptic Drugs. Asian J. Pharm. Tech. 2014; Vol. 4: Issue 3, Pg 117-130.
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