Volume No. :   4

Issue No. :  4

Year :  2014

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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A Validated RP-HPLC Method for Simultaneous Estimation of Pseudoephedrine and Terfinadine in its Bulk and Pharmaceutical Dosage forms



Address:   G. Kumaraswamy1*, Gandla Lalitha4, K. Swetha2, R. Suthakaran2, G. Ramesh Babu3
1Research Scholar, Department of Pharmaceutical Analysis, Jawaharlal Nehru Technological University Kakinada, Kakinada - 533 003-Andhra Pradesh, India.
2Department of Pharmaceutical analysis and QA, Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad-500097.Telangana.
3Chaithanya College of Pharmacy, Markapur, Prakasham (Dist). A.P. India
4Chilkur Balaji College of Pharmacy, Aziz Nagar, Hyderabad, Telangana.
*Corresponding Author
DOI No:

ABSTRACT:
The present work deals with the development of a precise, accurate, simple, specific, reliable and less time consuming RP-HPLC method for the estimation of Pseudoephedrine and Terfinadine tablets .The chromatographic separation was achieved on a Inertsil C18 ODS (4.6 x 250mm, 5┬Ám) with a mobile phase combination of methanol and water (50:50) v/v at a flow rate of 1.0 ml/min, and the detection was carried out by using PDA detector at 290 nm. Ambient column temperature has maintained. The total run time was 10mins.The retention time of Pseudoephedrine and Terfinadine were found to be 2.9 min. and 3.5 min. respectively. The performance of the method was validated according to the present ICH guidelines.
KEYWORDS:
RP-HPLC Method; Pseudoephedrine and Terfinadine; tablet dosage forms; PDA Detection.
Cite:
G. Kumaraswamy, Gandla Lalitha, K. Swetha, R. Suthakaran, G. Ramesh Babu. A Validated RP-HPLC Method for Simultaneous Estimation of Pseudoephedrine and Terfinadine in its Bulk and Pharmaceutical Dosage forms. Asian J. Pharm. Tech. 2014; Vol. 4: Issue 4, Oct.-Dec., Pg 200-204.
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