Volume No. :   5

Issue No. :  2

Year :  2015

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Evaluation of a Novel, Natural Badam Gum as a Sustained Release and Mucoadhesive Component of Tizanidine HCl Buccal Tablets



Address:   Harikrishnan.V1, Dr. S. Madhusudhan2, Dr. A. Santhiagu3
1Assistant Professor, National College of Pharmacy, Manassery Calicut, Kerala
2Assistant Professor, Department of Pharmacy, Faculty of Engg. & Technology, Annamalai University, Annamalai Nagar – 608002
3Associate Professor, School of Biotechnology, NIT Calicut, Kerala-673
*Corresponding Author
DOI No: 10.5958/2231-5713.2015.00012.4

ABSTRACT:
The objective of this research is a bioadhesive two layers controlled release tablets. The drug release and therefore the physical properties of tablet formulations using polymers badam gum at four levels were evaluated. Formulation containing 50% total polymer level was the best formulation. This formulation was tested in pH 6.8 dissolution medium and at 75 rotational speed. The drug release was 86.49% in 10th hour. 50% containing Badam Gum showed faster water uptake increased with increase in time to become fully hydrated. The mean values of force of detachment were grater for formulation containing 50 mg of Badam gum and the bioadhesive strength increased with increase in concentration of Badam gum. This study demonstrates the significance polymer for obtaining controlled release bioadhesive matrix and enhancing the characteristic of badam gum.
KEYWORDS:
Badam gum, Tizanidine HCl, bioadhesion, sustained release, controlled release, mucoadhesive.
Cite:
Harikrishnan.V, S. Madhusudhan, A. Santhiagu. Evaluation of a Novel, Natural Badam Gum as a Sustained Release and Mucoadhesive Component of Tizanidine HCl Buccal Tablets. Asian J. Pharm. Tech. 2015; Vol. 5: Issue 2, Pg 71-78.
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