Registered User Login
Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
News & Conferences
Volume No. :
Issue No. :
ISSN Print :
ISSN Online :
Click to Login
First Derivative Spectroscopic Method for Simultaneous Estimation of Pravstatin and Valsartan in Synthetic Mixture
Grishma S. Trivedi
Hasumati A Raj
Vineet C. Jain
Grishma S. Trivedi*, Hasumati A Raj, Vineet C. Jain
Shree Dhanvantary College of Pharmacy, Kim, Surat, Gujarat, India.
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Pravastatin and Valsartan in synthetic mixture using first order derivative zero-crossing method. Pravastatin showed zero crossing point at 262.40 nm while Valsartan showed zero crossing point at 248.20 nm. The dA/d? was measured at 248.20 nm for Pravastatin and 262.80 nm for Valsartan and calibration curves were plotted as dA/d? versus concentration, respectively. The method was found to be linear (r2>0.999) in the range of 2-10µg/ml for Pravastatin at 248.20 nm. The linear correlation was obtained (r2>0.9998) in the range of 8-40µg/ml for Valsartan at 262.40 nm. The limit of determination was 0.054µg/ml and 0.024µg/ml for Pravastatin and Valsartan, respectively. The limit of quantification was 0.166µg/ml and 0.074µg/ml for Pravastatin and Valsartan, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99% shows first order derivation zero crossing. The method was successfully applied for simultaneous determination of Pravastatin and Valsartan in binary mixture.
Pravastatin, Valsartan, First Derivative Method, Spectroscopic method.
Grishma S. Trivedi, Hasumati A Raj, Vineet C. Jain. First Derivative Spectroscopic Method for Simultaneous Estimation of Pravstatin and Valsartan in Synthetic Mixture. Asian J. Pharm. Tech. 2015; Vol. 5: Issue 2, Pg 83-90.
Visitor's No. :