Volume No. :   5

Issue No. :  3

Year :  2015

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Zero Order and Area under Curve Spectrophotometric Methods for Determination of Domperidone in Pharmaceutical Formulation



Address:   Audumbar Digambar Mali1*, Ritesh Bathe1, Ashpak Tamboli2
1Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India.
2Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India.
*Corresponding Author
DOI No: 10.5958/2231-5713.2015.00026.4

ABSTRACT:
Simple, fast and reliable spectrophotometry methods were developed for determination of Domperidonein bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Methanol.The quantitative determination of the drug was carried out using the zero order derivative values measured at286nm and the area under the curve method values measured at 279-293 nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Domperidone using 5-25µg/ml (r²=0.999 and r²=0.998) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Domperidonein tablets.
KEYWORDS:
Domperidone, UV visible spectrophotometry, AUC, Method Validation, Precission, Accuracy.
Cite:
Audumbar Digambar Mali, Ritesh Bathe, Ashpak Tamboli. Zero Order and Area under Curve Spectrophotometric Methods for Determination of Domperidone in Pharmaceutical Formulation. Asian J. Pharm. Tech. 2015; Vol. 5: Issue 3, July- Sept. Pg 182-187.
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