Volume No. :   5

Issue No. :  4

Year :  2015

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Design and Development of Dental Film Containing Aloe vera for the Treatment of Human Periodontal Diseases



Address:   Himansu Bhusan Samal1*, Itishree Jogamaya Das1, Ch. Niranjan Patra2, P. N. Murthy3
1Department of Pharmaceutics, Guru Nanak Institutions Technical Campus- School of Pharmacy, Ibrahimpatnam, Hyderabad-501506, India.
2Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha-760010, India.
3Royal College of Pharmacy and Health sciences, Berhampur, Odisha-760002, India.
*Corresponding Author
DOI No: 10.5958/2231-5713.2015.00036.7

ABSTRACT:
This study was designed to develop and evaluate dental film containing Aloe Vera extracts for the treatment of Periodontitis. Aloe Vera shows wide spectrum of antibacterial activity against a number of periodontal pathogen and hence selected for site specific delivery for the treatment of Periodontitis. Aloe vera is formulated into dental films by solvent casting technique using polymers such as Ethyl cellulose, Carbopol 971P and HPMC K4M with PEG 4000 as plasticizer and prepared films (F1-F8) were evaluated for various properties such as weight variation, tensile strength, moisture loss, drug content, in-vitro drug release, In-vitro antibacterial and stability studies. In-Vitro dissolution studies showed an initial burst release to achieve immediate therapeutic level of drug in periodontal pocket followed by a progressive fall and extended release of the drug with more uniformity for prolonged period of time. Stability studies did not show any significant changes with respect to content and appearance. In-vitro experiments demonstrated that the prepared film F8 represent a suitable dosage form to release Aloe vera for 96 h and considered as the Optimized formulation.
KEYWORDS:
Aloe vera; local delivery; Periodontitis; Controlled Release.
Cite:
Himansu Bhusan Samal, Itishree Jogamaya Das, Ch. Niranjan Patra, P. N. Murthy. Design and Development of Dental Film Containing Aloe vera for the Treatment of Human Periodontal Diseases. Asian J. Pharm. Tech. 2015; Vol. 5: Issue 4, Oct. - Dec., Pg 273-280.
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