Volume No. :   6

Issue No. :  2

Year :  2016

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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A Review on Self- Micro Emulsifying Drug Delivery System: Evident to improve the oral bioavailability of hydrophobic drugs



Address:   Dhiraj A. Khairnar1*, Avinash B. Darekar1, Ravindra B. Saudagar2
1Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjaneri, Dist.Nashik-422212, Maharashtra, India.
2Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjaneri, Dist.Nashik-422212, Maharashtra, India.
*Corresponding Author
DOI No: 10.5958/2231-5713.2016.00018.0

ABSTRACT:
The SMEDDS are the isotropic mixture of oil, surfactant and co-surfactant. SMEDDS solve the problem of all BCS class of drug such as solubility, high molecular weight, pre systemic first pass effect, enzymatic degradation, gastric irritation and also increase the bioavailability and stability of drug. Currently a number of technologies are available to deal with the poor solubility, dissolution rate and bioavailability of insoluble drugs one of them is Self-Micro Emulsifying Drug Delivery Systems (SMEDDS). lipid based formulations, self-microemulsifying formulations (droplet size <100 nm) are evident to improve the oral bioavailability of hydrophobic drugs primarily due to their efficiency in facilitating solubilization and in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented.
KEYWORDS:
SMEDDS, Hydrophobic drugs, surfactant, oil, co-surfactant, bioavailability.
Cite:
Dhiraj A. Khairnar, Avinash B. Darekar, Ravindra B. Saudagar. A Review on Self- Micro Emulsifying Drug Delivery System: Evident to improve the oral bioavailability of hydrophobic drugs. Asian J. Pharm. Tech. 2016; 6(2): 131-134.
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