Volume No. :   6

Issue No. :  2

Year :  2016

ISSN Print :  2231-5705

ISSN Online :  2231-5713


Registration

Allready Registrered
Click to Login

Formulation and in vitro Evaluation of Mouth Dissolving Tablets of Labetalol HCl by Sublimation Method



Address:   Rebecca1, Ravi Kumar2*, Narayana Swamy VB3
1M.Pharm (Pharmaceutics) Research Scholar, Karavali College of Pharmacy, Mangalore
2Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore
3Department of Pharmacognosy, Karavali College of Pharmacy Vamanjoor, Mangalore
*Corresponding Author
DOI No: 10.5958/2231-5713.2016.00010.6

ABSTRACT:
The objective of this research was to formulate fast dissolving tablets of Labetalol HCl that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Fast dissolving tablets of Labetalol HCl were prepared by direct compression method by using sublimation method. Seven formulations were prepared and evaluated for hardness, thickness, friability, weight variation, drug content, in vitro disintegration time, in vitro dispersion time, wetting time, water absorption ratio and in vitro dissolution studies. FTIR and DSC studies revealed that there was no chemical interaction between the drug and the excipients. Formulation S5 were found to be the best on the basis of wetting time, in vitro disintegration time and in vitro drug release. The formulation S5 containing Crospovidone as superdisintegrant and ammonium bicarbonate as subliming agent were found to be the optimized combinations. Stability studies were carried out for S5 at 400C±20C/75%±5% RH for 60 days. The results of stability studies indicated no significant changes with respect to physicochemical properties, in vitro disintegration time, wetting time and in vitro drug release.
KEYWORDS:
Fast dissolving tablets, Labetalol HCl, Superdisintegrant, Direct compression, Sodium starch glycollate, ammonium bicarbonate, camphor
Cite:
Rebecca, Ravi Kumar, Narayana Swamy VB. Formulation and in vitro Evaluation of Mouth Dissolving Tablets of Labetalol HCl by Sublimation Method. Asian J. Pharm. Tech. 2016; 6(2): 70-80.
[View HTML]      [View PDF]



Visitor's No. :   85905