Volume No. :   6

Issue No. :  4

Year :  2016

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Simultaneous Formulation, Evaluation and Estimation of Self Emulsifying Drug Delivery System (SEDDS) of Ibuprofen Tablet Dosage form using Varied quantities of Goat Fat as an Excipient and Tween-60 as a Surfactant



Address:   Abdul Saleem Mohammad1*, Nuha Rasheed2, Mohammed Nayeem Uddin3, Hajera Hafeez4
1Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India.
2Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India.
3Department of Pharmacology, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India.
4Department of Pharmaceutics, Global College of Pharmacy, Beside to Moinabad Police Station, Moinabad, Ranga Reddy (Dist)-501504, Telangana, India. *Corresponding Author
DOI No:

ABSTRACT:
The aim of present study confirmed that the SEDDS formulation can be used as a possible alternate to traditional or classical formulations of Ibuprofen to improve its bioavailability using varied quantities of goat fat as an excipient and tween 60 as a surfactant which is a drug in the nonsteroidal anti-inflammatory drug (NSAID) class used for treating pain, fever and inflammation which is also known to be isobutylphenylpropanoic acid. The investigation proved that the formulated dosage forms showed good release profile as well as acceptable tablet properties. The batches with higher tween60: goat fat content ratios gave better release rates. The SEDDS of Ibuprofen was successfully prepared and the tablets prepared passed the various evaluation tests conducted. This method has advantage of reliance on cheap raw materials such as goat fat with fewer processing steps, best suited for lipophilic drugs where the resulting emulsification gives faster dissolution rates and absorption. In-vivo evaluation of this novel dosage form is currently in progress. Self-emulsifying drug delivery systems are a promising approach for the formulation of lipophilic drug compounds having poor aqueous solubility. The oral delivery of hydrophobic drugs can be made possible by SEDDSs which have been shown to improve oral bioavailability substantially. From the formulation point of view it is necessary to consider the emulsification properties of lipid base vehicle and the solubility of drug in the lipid surfactant mixture to form a completely miscible solution so as to solubilize adequate quantities of drug in lipid vehicle. Lipids have an important role in absorption process. Thus, SEDDS plays an important role in the formulation of poorly water soluble drugs and enhancing their bioavailability.
KEYWORDS:
SEEDS, surfactants, Tween-60, Goat fat, Beer’s law, lipophilic.
Cite:
Abdul Saleem Mohammad, Nuha Rasheed, Mohammed Nayeem Uddin, Hajera Hafeez. Simultaneous Formulation, Evaluation and Estimation of Self Emulsifying Drug Delivery System (SEDDS) of Ibuprofen Tablet Dosage form using Varied quantities of Goat Fat as an Excipient and Tween-60 as a Surfactant. Asian J. Pharm. Tech. 2016; 6(4): 257-265.
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