Volume No. :   7

Issue No. :  1

Year :  2017

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Optimization of Various Grades of HPMC for Development of Sustained Release Matrix Tablets of Theophylline.



Address:   Godbole Ajeet Madhukar1, Patel Bhautik V2, Somnache Sandesh Narayan1*, Prajapati Ashish R2, Yadav Pradeep2
1Department of Pharmaceutics, PES’S Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda-403401, Goa, India.
2Department of Pharmaceutics, S.E.T’S College of Pharmacy, Dharwad, Karnataka (India).
*Corresponding Author
DOI No: 10.5958/2231-5713.2017.00004.6

ABSTRACT:
Theophylline is a bronchodilator drug, used in treatment of asthma. The conventional dosage forms of Theophylline releases the entire drug in just few minutes and therefore the therapeutic concentrations will be maintained for a short period of time. This may leads to administration of subsequent dose. To overcome this, present study was aimed to develop the dosage form of Theophylline which will release the drug up to 12 hours. The matrix tablets of Theophylline were developed using different concentrations of various grades of HPMC and were evaluated for various pre-compression and post compression parameters. The data obtained was analyzed using linear model (Historical Data) of Design Expert 8.0.7.1(Trial version). Based on the results obtained, it was concluded that the Formulation F9 containing HPMC E15LV is suitable to develop sustained release matrix table of Theophylline which can release more than 50 % drug in first 5 hours and more that 90 % of the drug at the end of 9th hour extended up to 12 hours.
KEYWORDS:
Swellable polymer, optimization of formulation, design of experiment, theophylline matrix tablet.
Cite:
Godbole Ajeet Madhukar, Patel Bhautik V, Somnache Sandesh Narayan, Prajapati Ashish R, Yadav Pradeep. Optimization of Various Grades of HPMC for Development of Sustained Release Matrix Tablets of Theophylline. Asian J. Pharm. Tech. 2017; 7(1): 19-26.
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