Volume No. :   7

Issue No. :  1

Year :  2017

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Solid State Characterization of Acyclovir-Nicotinamide Binary Systems using Solvent Evaporation Technique



Address:   Agnes Nuniek Winantari1,2*, Dwi Setyawan1, Siswandono1, Sundani Nurono Soewandhi3
1Faculty of Pharmacy, Airlangga University, Jl. Dharmawangsa Dalam Surabaya 60286, Indonesia
2Faculty of Pharmacy, University of Surabaya, Jl. Raya Kalirungkut, Surabaya , 60293 Indonesia
3School of Pharmacy, Bandung Institute of Technology, Jl. Ganesha No. 10, Bandung 40132, Indonesia
*Corresponding Author
DOI No: 10.5958/2231-5713.2017.00006.X

ABSTRACT:
Objective of the study is to characterize acyclovir-nicotinamide binary systems (AN). Methods of cocrystallization was solvent evaporation in equimolar ratio between acyclovir and nicotinamide using ethanol and methanol. The binary systems were characterized by polarization microscope, Differential Scanning Calorimetry (DSC) and Powder X-Ray Diffraction (PXRD). Physical characterization showed that AN binary systems have unique crystal habit in microscopic. A new endothermic peak appears at 123.69 oC. The PXRD patterns of AN binary systems after cocrystallization are different from pure components which specific peak was found on 2? = 11.27o (AN in ethanol); 21.05o (AN in methanol).
KEYWORDS:
Acyclovir, nicotinamide, binary systems, solvent evaporation, ethanol, methanol.
Cite:
Agnes Nuniek Winantari1, Dwi Setyawan, Siswandono, Sundani Nurono Soewandhi. Solid State Characterization of Acyclovir-Nicotinamide Binary Systems using Solvent Evaporation Technique. Asian J. Pharm. Tech. 2017; 7(1): 33-36.
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