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Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
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Gold Nanoparticle-Small Drug Molecule Conjugates: Therapeutic Applications and Benefits as Compared to Free Drug
Mahendra Singh Ashawat
Pravin Kumar, Mahendra Singh Ashawat, Vinay Pandit
Department of Pharmaceutics, Laureate Institute of Pharmacy, Kangra, H. P, India-177101
Gold nanoparticles (AuNPs) have been profoundly investigated for drug delivery applications. Various widely used small drugs molecules when conjugated either covalently or non-covalently with the AuNPs, showed improved therapeutic effect with reduced dose and adverse effects as compared to drug alone. This review focuses on therapeutic efficiency of AuNPs-small drug molecule conjugates as anti-cancer, anti-bacterial, anti-retroviral and anti-arthritic agents. The basic approaches of conjugation, brief of procedure followed for activity determination and mechanism of action of conjugates have also been discussed.
Nanoparticles, Drug conjugates, Anti-cancer, Anti-bacterial, Drug delivery.
Pravin Kumar, Mahendra Singh Ashawat, Vinay Pandit. Gold Nanoparticle-Small Drug Molecule Conjugates: Therapeutic Applications and Benefits as Compared to Free Drug. Asian J. Pharm. Tech. 2018; 8 (1): 52-62.
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