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Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
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Merlin. N. J
Alfiya. A. R
Shaiju S Dharan
Merlin. N. J*, Alfiya. A. R, Shaiju S Dharan
Department of Pharmacology Ezhuthachan College of Pharmaceutical Sciences Marayamuttom Trivandrum
Toxicokinetics (TK) is ‘the generation of pharmacokinetic data, either as an integral component in the conduct of non-clinical toxicity studies or in specially designed supportive studies, to assess systemic exposure. Physiologically based toxicokinetic [(PBTK), or alternatively referred to as physiologically based pharmacokinetic (PBPK)] models are quantitative descriptions of absorption, distribution, metabolism, and excretion of chemicals. Toxicokinetics, toxicodynamics and toxicogenomics (TK/TD/TG) methods are the potential tools in human health risk assessment.
Toxicokinetics, PBTK model, PBPK model, safety assessment, Drug development.
Merlin. N. J, Alfiya. A. R, Shaiju S Dharan. Toxicokinetics-A Review. Asian J. Pharm. Tech. 2018; 8 (3):182-185.
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