Volume No. :   8

Issue No. :  3

Year :  2018

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Toxicokinetics-A Review



Address:   Merlin. N. J*, Alfiya. A. R, Shaiju S Dharan
Department of Pharmacology Ezhuthachan College of Pharmaceutical Sciences Marayamuttom Trivandrum
*Corresponding Author
DOI No: 10.5958/2231-5713.2018.00029.6

ABSTRACT:
Toxicokinetics (TK) is ‘the generation of pharmacokinetic data, either as an integral component in the conduct of non-clinical toxicity studies or in specially designed supportive studies, to assess systemic exposure. Physiologically based toxicokinetic [(PBTK), or alternatively referred to as physiologically based pharmacokinetic (PBPK)] models are quantitative descriptions of absorption, distribution, metabolism, and excretion of chemicals. Toxicokinetics, toxicodynamics and toxicogenomics (TK/TD/TG) methods are the potential tools in human health risk assessment.
KEYWORDS:
Toxicokinetics, PBTK model, PBPK model, safety assessment, Drug development.
Cite:
Merlin. N. J, Alfiya. A. R, Shaiju S Dharan. Toxicokinetics-A Review. Asian J. Pharm. Tech. 2018; 8 (3):182-185.
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