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Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
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Design and Development of Solid Self-Microemulsifying Drug Delivery of Gefitinib
Ghadge Dhairyasheel, Yadav Adhikrao, Gharge Varsha*
Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India-415015
Objective: Solid self-microemulsifying drug delivery system (SMEDDS) of Gefitinib was aimed at overcoming the problems of poor solubility and bioavailability. Methodology: The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region using a dilution method. The prepared formulations of SMEDDS were evaluated for their drug content, loading efficiency, morphology, globule size determination. Results: The formulation containing gefitinib (25 mg), oleic acid (20% w/w), tween 80 (30% w/w), propylene glycol (10% w/w) and water (40% w/w) was concluded to be optimized. The optimized SMEDDS and solid-SMEDDS exhibited 84.4 % in vitro drug release up to 60 min, which was significantly higher than that of the pure drug. Solid-SMEDDS may be considered as a better solid dosage form as solidified formulations are more ideal than liquid ones in terms of its stability. Conclusion: These results suggest the potential use of SMEDDS and solid-SMEDDS to improve the dissolution and hence oral bioavailability of poorly water-soluble drugs like Gefitinib through oral route.
Gefitinib, solid-SMEDDS, Ternary phase diagrams, in vitro drug release,). In-Vitro Anticancer Activity Study
Ghadge Dhairyasheel, Yadav Adhikrao, Gharge Varsha. Design and Development of Solid Self-Microemulsifying Drug Delivery of Gefitinib. Asian J. Pharm. Tech. 2018; 8 (4):193-199.
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