Volume No. :   9

Issue No. :  1

Year :  2019

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Formulation, Optimization and Evaluation of Glibenclamide Transdermal Patches by using chitosan Polymer



Address:   AVS Madhu Latha*, T Naga Ravikiran, J N Suresh Kumar
Department of Pharmaceutics, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Andhra Pradesh, India.
*Corresponding Author
DOI No: 10.5958/2231-5713.2019.00001.1

ABSTRACT:
Transdermal drug delivery system (TDDS) also known as “patches “are dosage form designed to deliver the therapeutically effective amount of drug across the patient skin. Glibenclamide is the drug of choice mainly prescribed for the treatment of type 2 diabetes. Oral therapy with Glibenclamide comprises problems of bioavailability fluctuations and may be associated with severe hypoglycaemia and gastric disturbances. As a potential for convenient, safe and effective antidiabetic therapy, the rationale of this study was to develop a TDDS for Glibenclamide. In this study, matrix type transdermal drug delivery system of glibenclamide, an antidiabetic drug were prepared by solvent casting method using different polymers like HPMC, Chitosan in varied ratios. Glycerine was used as plasticizer. Chitosan developing polymer was utilized in TDDS. Chitosan has film forming ability, bioadhesive and absorption enhancing properties. Physical parameters such as moisture content, tensile strength, percentage elongation, and folding endurance were evaluated. Release studies revealed adequate release rates from transdermal films having polymer concentration Chitosan /HPMC (75:25) D4 showed optimum sustained release characteristics.
KEYWORDS:
Chitosan, HPMC5cps, Glibenclamide, Diabetes, FTIR Studies, plasticizer.
Cite:
AVS Madhu Latha, T Naga Ravikiran, J N Suresh Kumar. Formulation, Optimization and Evaluation of Glibenclamide Transdermal Patches by using chitosan Polymer. Asian J. Pharm. Tech. 2019; 9(1):01-07.
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