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Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
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Method Development and Validation for the Quantification of Cyamemazine tartrate (CYMT) in bulk and its marketed formulation by using UV Spectroscopy
K. B. Chandra Sekhar
B. Siva Sai Kiran
Anjaneyulu.Vinukonda1*, K. B. Chandra Sekhar2, Shaik Muneer2, B. Siva Sai Kiran2, Akkimi Padma2, Pallavi A2
1Senior Research Scientist, Alembic Pharmaceuticals Ltd.
2Department of Pharmaceutical Analysis, JNTUA-Oil Technological and Pharmaceutical Research Institute, Ananthapuramu-515001. A.P, India.
A simple, precise and accurate UV spectroscopic method has been developed for the quantification of cyamemazine tartrate in bulk and its dosage form. In this study, ethanol was used as a solvent and the absorption maxima was found to be 270nm. The drug followed the Beer-Lambert’s law in the concentration range of 2-12 µg/ml with correlation coefficient (R2) 0.999. Percentage mean recovery of the drug was found to be within limit and the relative standard deviation (SD) was found to be less than 2 % in precision studies. All the validation parameters satisfied by accordance with ICH guidelines. This method can be suggest to routine quality control analysis of cyamemazine tartrate in bulk and its dosage forms.
Cyamemazine tartrate, UV Spectroscopy, Beer-lambert’s law, ICH Guidelines.
Anjaneyulu.Vinukonda, K. B. Chandra Sekhar, Shaik Muneer, B. Siva Sai Kiran, Akkimi Padma, Pallavi A. Method Development and Validation for the Quantification of Cyamemazine tartrate (CYMT) in bulk and its marketed formulation by using UV Spectroscopy. Asian J. Pharm. Tech. 2019; 9(1):08-10.
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