Volume No. :   9

Issue No. :  2

Year :  2019

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Formulation and In Vitro Characterisation Oxcarbazepine Controlled Release Tablets



Address:   Sk. Asha Begum1*, B. Bhargavi2, J. Divya3, K. Swetha4, Sk. Zareena5, Lohitha S6, Ramya Sri S7
1,2,3,4,5,6Nimra College of Pharmacy, Ibrahimpatnam, Krishna District, Andhra Pradesh
7Department of Pharmaceutics, University of Technology, Osmania University, Hyderabad, Telangana
*Corresponding Author
DOI No: 10.5958/2231-5713.2019.00018.7

ABSTRACT:
In the present work, an attempt has been made to develop controlled release tablets of oxcarbazepine by selecting of HPMC and Poly ethylene oxide as retarding polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F10 formulation showed maximum % drug release i.e., 98.84 % in 12 hours hence it is considered as optimized formulation F10 which contains Ethylcellulose N50 (20 mg) . Whereas the formulations with HPMC K15M showed more retarding with increasing concentration of polymer. The formulations with Poly ethylene oxide were unable to produce the desired drug release pattern.
KEYWORDS:
Oxcarbazepine, Poly ethylene oxide, Ethylcellulose N50, contolled release tablets.
Cite:
Sk. Asha Begum, B. Bhargavi, J. Divya, K. Swetha, Sk. Zareena, Lohitha S, Ramya Sri S. Formulation and In Vitro Characterisation Oxcarbazepine Controlled Release Tablets. Asian J. Pharm. Tech. 2019; 9(2):107-111.
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