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Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
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Colorimetric Estimation of Nebivolol Hydrochloride in Bulk and Pharmaceutical Dosage Form
Syed Sagheer Ahamed
Nirmal. T. Havannavar
Syed Shariff Miyan
Syed Sagheer Ahamed*1, Mohamed Khaleel2, Nirmal. T. Havannavar3, Syed Shariff Miyan4
Department of Pharmaceutical Analysis and Quality Assurance, M.M.U College of Pharmacy, Ramanagara
A simple, sensitive and accurate colorimetric estimation method was developed for the assay of Nebivolol hydrochloride in pure drug and tablet dosage form. The yellowish-orange coloured chromogen so produced was measured at 392nm for Nebivolol hydrochloride. It obeyed beer’s law at the concentrations of 4-36µg/ml with coefficient of correlation (r2) of 0.999. Limit of detection (LOD) was found to be 2.558µg/ml and Limit of quantitation (LOQ) was found to be 3.764µg/ml. Validation of the method yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness. The excipients found in the formulation did not hamper the method.
Nebivolol hydrochloride, antihypertensive, colorimetry, method validation.
Syed Sagheer Ahamed, Mohamed Khaleel, Nirmal. T. Havannavar, Syed Shariff Miyan. Colorimetric Estimation of Nebivolol Hydrochloride in Bulk and Pharmaceutical Dosage Form. Asian J. Pharm. Tech. 2019; 9(4):253-259.
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