Volume No. :   9

Issue No. :  4

Year :  2019

ISSN Print :  2231-5705

ISSN Online :  2231-5713


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Colorimetric Estimation of Nebivolol Hydrochloride in Bulk and Pharmaceutical Dosage Form



Address:   Syed Sagheer Ahamed*1, Mohamed Khaleel2, Nirmal. T. Havannavar3, Syed Shariff Miyan4
Department of Pharmaceutical Analysis and Quality Assurance, M.M.U College of Pharmacy, Ramanagara
*Corresponding Author
DOI No: 10.5958/2231-5713.2019.00042.4

ABSTRACT:
A simple, sensitive and accurate colorimetric estimation method was developed for the assay of Nebivolol hydrochloride in pure drug and tablet dosage form. The yellowish-orange coloured chromogen so produced was measured at 392nm for Nebivolol hydrochloride. It obeyed beer’s law at the concentrations of 4-36µg/ml with coefficient of correlation (r2) of 0.999. Limit of detection (LOD) was found to be 2.558µg/ml and Limit of quantitation (LOQ) was found to be 3.764µg/ml. Validation of the method yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness. The excipients found in the formulation did not hamper the method.
KEYWORDS:
Nebivolol hydrochloride, antihypertensive, colorimetry, method validation.
Cite:
Syed Sagheer Ahamed, Mohamed Khaleel, Nirmal. T. Havannavar, Syed Shariff Miyan. Colorimetric Estimation of Nebivolol Hydrochloride in Bulk and Pharmaceutical Dosage Form. Asian J. Pharm. Tech. 2019; 9(4):253-259.
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