Sarjavalagi Vishal Gopal, Prabhat Kumar Chaurasia, Harshitha Arun Pardhe, Singh Suryansh Santosh, Narayan Sah Sonar
Sarjavalagi Vishal Gopal*1, Prabhat Kumar Chaurasia2, Harshitha Arun Pardhe3, Singh Suryansh Santosh2, Narayan Sah Sonar3
1M. Pharm, Dept. of Pharmaceutics, Oxbridge College of Pharmacy, Bengaluru, Karnataka.
2M. Pharm, Dept. of Pharmaceutics, Mallige College of Pharmacy, Bengaluru, Karnataka.
3M. Pharm, Dept. of Pharmacology, Mallige College of Pharmacy, Bengaluru, Karnataka.
Volume - 10,
Issue - 4,
Year - 2020
Gastroretentive drug delivery system is a novel drug delivery system that has an upper hand due to its ability to maintain prolonged stomach retention and thereby increase the stomach residence time of drugs and also enhance the bioavailability of drugs. Oral sustained drug delivery system is complicated by reduced stomach residence time (GRTs) and erratic stomach emptying time etc. In order to overcome these limitations, various approaches have been proposed to increase the gastric residence of drug delivery systems in the upper part of the gastrointestinal tract peptic ulcer, stomach ulcer, or gastric ulcer, also known as peptic ulcer disease, is a very common chronic stomach disorder that is mainly caused by stomach lining damage. Various factors such as pepsin, gastric acid, H. Pylori, NSAIDs, prostaglandins, mucus, bicarbonate, and mucosal blood flow play an important role in the development of peptic ulcers and so on. In this review article we concentrate on some important mechanisms for the delivery of gastro-retentive drugs (GRDDS) (floating, bioadhesive, high density, swellable, raft forming, and magnetic systems) which will be useful in the treatment of peptic ulcer in different dosage types. This manuscript highlights various developmental approaches, Comparison between Conventional drug delivery systems and Gastro retentive Drug delivery systems, characterization aspects, potential drug candidates, unsuitable drug candidates, List of commercialized gastro-retentive drug delivery system, advantages and applications of gastroretentive systems.
Cite this article:
Sarjavalagi Vishal Gopal, Prabhat Kumar Chaurasia, Harshitha Arun Pardhe, Singh Suryansh Santosh, Narayan Sah Sonar. Gastroretentive Drug Delivery System: A Systematic Review. Asian J. Pharm. Tech. 2020; 10(4):278-284. doi: 10.5958/2231-5713.2020.00046.X
Sarjavalagi Vishal Gopal, Prabhat Kumar Chaurasia, Harshitha Arun Pardhe, Singh Suryansh Santosh, Narayan Sah Sonar. Gastroretentive Drug Delivery System: A Systematic Review. Asian J. Pharm. Tech. 2020; 10(4):278-284. doi: 10.5958/2231-5713.2020.00046.X Available on: https://ajptonline.com/AbstractView.aspx?PID=2020-10-4-10
1. Setia M, Kumar K, Teotia D. Gastro-retentive floating beads a new trend of drug delivery system. Journal of drug delivery and therapeutics. 2018 May 22;8(3):169-80.
2. Chugh CH, Nanda AR. Gastroretentive drug delivery systems-A review. Int J pharma bio sci. 2017;8(1):62-8.
3. Arunachalam A, Karthikeyan M, Konam K, et al. Floating drug delivery systems: A review. International Journal of Research in Pharmaceutical Sciences. 2011 Jan 20;2(1):76-83.
4. Vedha H, Chaudhary J. The recent developments on gastric floating drug delivery system: An overview. Journal of Pharmaceutical Technology and Research. 2010;2(1):524-34.
5. Veerareddy PR, Bajjuri S, Sanka K, et al. Formulation and evaluation of gastroretentive dosage form of ofloxacin. Stamford Journal of Pharmaceutical Sciences. 2011;4(1):9-18.
6. Hwang SJ, Park H, Park K. Gastric retentive drug-delivery systems. Critical Reviews™ in Therapeutic Drug Carrier Systems. 1998;15(3).
7. Shaha SH, Patel JK, Pundarikakshudu K, et al. An overview of a gastro-retentive floating drug delivery system. Asian journal of pharmaceutical sciences. 2009 Jan;4(1):65-80.
8. Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. Journal of Controlled release. 2000 Feb 3;63(3):235-59.
9. Aslam R, Mehmood Y, Khan S, et al. Techniques and polymers used to design Gastroretentive drug delivery systems–a review. World journal of pharmacy and pharmaceutical sciences. 2014 Sep 27;3(12):970-110.
10. Badoni A, Ojha A, Gnanarajan G, et al. Review on gastro retentive drug delivery system. The pharma innovation. 2012 Oct 1;1(8, Part A):32.
11. Rao CS, Sharath K, Kowmudi V, et al. Development and in-vitro evaluation of cefpodoxime proxetil gastro-retentive floating tablets. International Journal of Applied Pharmaceutical Sciences and Research. 2016 Sep 5;1(1):31-41.
12. Kajal A. Prajapati, Anil G. Raval, Yogesh K. Patel, et al. Agraval. Gastroretentive drug delivery system therapeutic management of peptic ulcer in geriatric patient. World J Pharm Sci 2018; 6(11): 71-83.
13. Bhardwaj L, Sharma PK, Malviya R. A short review on gastro retentive formulations for stomach specific drug delivery: special emphasis on floating in situ gel systems. African journal of basic and applied sciences. 2011;3(6):300-12.
14. Sharma AR, Khan A. Gastroretentive drug delivery system: an approach to enhance gastric retention for prolonged drug release. International journal of pharmaceutical sciences and research. 2014 Apr 1;5(4):1095.
15. Swetha S, Allena RT, Gowda DV. A Comprehensive review on gastroretentive drug delivery systems. International Journal of Research in Pharmaceutical and Biomedical Science. 2012;3(3):1285-93.
16. Pawar VK, Kansal S, Garg G, et al. Gastroretentive dosage forms: a review with special emphasis on floating drug delivery systems. Drug delivery. 2011 Feb 1;18(2):97-110.
17. Gurnany E, Singhai P, Soni A, et al. Gastro Retentive Drug Delivery System-A Review. Journal of Pharmacy Research. 2011 Jun;4(6):1899-908.
18. Jassal M, Nautiyal U, Kundlas J. A review: Gastroretentive drug delivery system (grdds). Indian journal of pharmaceutical and biological research. 2015 Mar 31;3(01):82-92.
19. Wang J, Tauchi Y, Deguchi Y, et al. Positively charged gelatin microspheres as gastric mucoadhesive drug delivery system for eradication of H. pylori. Drug delivery. 2000 Jan 1;7(4):237-43.
20. Smart JD. The basics and underlying mechanisms of mucoadhesion. Advanced drug delivery reviews. 2005 Nov 3;57(11):1556-68.
21. Kakar S, Batra D, Singh R, et al. Magnetic microspheres as magical novel drug delivery system: A review. Journal of acute disease. 2013 Jan 1;2(1):1-2.
22. Prajapati VD, Jani GK, Khutliwala TA, et al. Raft forming system—an upcoming approach of gastroretentive drug delivery system. Journal of controlled release. 2013 Jun 10;168(2):151-65.
23. Tripathi J, Thapa P, Maharjan R, et al. Current state and future perspectives on gastroretentive drug delivery systems. Pharmaceutics. 2019 Apr;11(4):193.
24. Adibkia K, Ghanbarzadeh S, Mohammadi G, et al. Gastro retentive drug delivery systems: A review. Journal of Reports in Pharmaceutical Sciences. 2013 Jul 1;2(2):100-14.
25. Fabregas JL, Claramunt J, Cucala J, et al. “In-Vitro” Testing of an Antacid Formulation with Prolonged Gastric Residence Time (Almagate Flot-Coat®). Drug development and industrial pharmacy. 1994 Jan 1;20(7):1199-212.
26. Jain NK. Progress in controlled and novel drug delivery systems. CBSS. Gopalakrishnan et al. Journal of Pharmaceutical Science and Technology. Publishers and Distributors, New Delhi, Bangalore. 2004;3(2):84-5.
27. Goyal M, Prajapati R, Purohit KK, et al. Floating drug delivery system. Journal of current pharmaceutical research. 2011; 5(1):7-18.
28. Mandal UK, Chatterjee B, Faria GS. Gastro-retentive drug delivery system and their in vivo success: A recent update. A recent update. Asian Journal of Pharmaceutical Sciences. 2016; 11(5):575-84.