Author(s): Om Nandkishor Bhandurge, Sarita K Metangale, Rushikesh G Navale, Shatrughna U Nagrik, Shivshankar D Mhaske, Harshal Anwane

Email(s): ombhandurge25@gmail.com

DOI: 10.52711/2231-5713.2025.00042   

Address: Om Nandkishor Bhandurge*¹, Sarita K Metangale², Rushikesh G Navale³, Shatrughna U Nagrik⁴, Shivshankar D Mhaske⁵, Harshal Anwane⁶
1,2,3Students of Bachelor of Pharmacy, Satyajeet College of Pharmacy, Khandala, Mehkar - 443301.
4Assistant Professor, Department of Pharmacology, Satyajeet College of Pharmacy, Khandala, Mehkar - 443301.
5Principal of Satyajeet, College of Pharmacy, Khandala, Mehkar - 443301.
6Assistant Professor, Department of Pharmaceutical Chemistry, Satyajeet College of Pharmacy, Khandala, Mehkar - 443301.
*Corresponding Author

Published In:   Volume - 15,      Issue - 3,     Year - 2025


ABSTRACT:
Sesbania grandiflora, also known as the "Vegetable Hummingbird" or "Agati," is a plant with notable medicinal properties that have been utilized in various traditional healing practices. Recently, its potential benefits, particularly in migraine treatment, have attracted growing interest. The plant is rich in bioactive compounds like flavonoids, alkaloids, and saponins, which are known for their anti-inflammatory, pain-relieving, and neuroprotective effects. Migraines, a neurological disorder marked by intense headaches and related symptoms, can potentially be relieved by natural remedies with such characteristics. Preliminary studies suggest that extracts from Sesbania grandiflora may help reduce migraine symptoms by influencing pain pathways, lowering inflammation, and encouraging vasodilation. While traditional applications and early research support its effectiveness, further clinical studies are necessary to determine the ideal dosage, mechanisms, and long-term safety of Sesbania grandiflora for migraine treatment. This Review highlights the promise of Sesbania grandiflora as a natural alternative for managing migraines and underscores the importance of continued research in phytotherapy.


Cite this article:
Om Nandkishor Bhandurge, Sarita K Metangale, Rushikesh G Navale, Shatrughna U Nagrik, Shivshankar D Mhaske, Harshal Anwane. Review on Sesbania grandiflora used in the Treatment of Migraine. Asian Journal of Pharmacy and Technology. 2025; 15(3):277-5. doi: 10.52711/2231-5713.2025.00042

Cite(Electronic):
Om Nandkishor Bhandurge, Sarita K Metangale, Rushikesh G Navale, Shatrughna U Nagrik, Shivshankar D Mhaske, Harshal Anwane. Review on Sesbania grandiflora used in the Treatment of Migraine. Asian Journal of Pharmacy and Technology. 2025; 15(3):277-5. doi: 10.52711/2231-5713.2025.00042   Available on: https://ajptonline.com/AbstractView.aspx?PID=2025-15-3-10


REFERENCE: 
1.    Ansil, P. N., Soumya, S., and Shafna, S. (2022). Sesbania grandiflora: A Potential Source of Phytopharmaceuticals. AkiNik Publications 169, C-11, Sector-3, Rohini, Delhi-110085, India.
2.    Ashina, M., Katsarava, Z., Do, T. P., Buse, D. C., Pozo-Rosich, P., Özge, A., ... and Lipton, R. B. (2021). Migraine: epidemiology and systems of care. The Lancet, 397(10283), 1485-1495.
3.    Amiri, P., Kazeminasab, S., Nejadghaderi, S. A., Mohammadinasab, R., Pourfathi, H., Araj-Khodaei, M., and Safiri, S. (2022). Migraine: a review on its history, global epidemiology, risk factors, and comorbidities. Frontiers in neurology, 12, 800605.
4.    Moretti, R., Pansiot, J., Bettati, D., Strazielle, N., Ghersi-Egea, J. F., Damante, G., and Gressens, P. (2015). Blood-brain barrier dysfunction in disorders of the developing brain. Frontiers in neuroscience, 9, 40.
5.    Sheikh, H. U., and Mathew, P. G. (2012). Acute and preventive treatment of migraine headache. Techniques in regional anesthesia and pain management, 16(1), 19-24.
6.    Ambastha, S., & Sharan, L. (2023). In Vitro Antioxidant Activity and GC-MS Analysis of Sesbania grandiflora (L.) Pres. Leaves. South Asian Journal of Experimental Biology, 13(4).
7.    Mahmud, N. (2020). In vitro Bioactivities of Single or Combined Extracts from Three Selected Asian Vegetables (Doctoral dissertation, University of Malaya (Malaysia)).
8.    Kaur, A., Singh, S., Mujwar, S., & Singh, T. G. (2025). Molecular Mechanisms Underlying the Therapeutic Potential of Plant-Based α-Amylase Inhibitors for Hyperglycemic Control in Diabetes. Current Diabetes Reviews, 21(8), e020724231486.
9.    Rana, A. J. (2022). A review on Sesbania grandiflora its effect on the treatment of dementia and neuro disease and other diseases (Doctoral dissertation, Kumaun University).
10.    Mans, D. R., Friperson, P., Djotaroeno, M., and Pawirodihardjo, J. (2022). Pharmacopeia: Part. Natural Drugs from Plants, 2, 183.
11.    Lim, T. K. (2013). Sesbania grandiflora. In Edible Medicinal and Non-Medicinal Plants: Volume 7, Flowers (pp. 889-902). Dordrecht: Springer Netherlands.
12.    Macha, M. A., Zargar, S. M., Bhat, A. A., & Uddin, S. (Eds.). (2025). Neglected and Underutilized Crops: Unveiling Potential for Cancer Drug Discovery.
13.    Antony, J., Saikia, M., T. Cheriyan, V., Kumar S, N., and John Anto, R. (2015). Sesbania: A Prospective Candidate to be Excavated for Anticancer Drugs. The Natural Products Journal, 5(4), 273-287.
14.    Arora, S., and Itankar, P. (2020). Polyphenol rich extract from Sesbania grandiflora (L.) Pers. bark reduces rheumatism by mediating the expression of NF kappa B in rats. Indian Journal of Experimental Biology (IJEB), 59(01), 44-53.
15.    Abo-Elghiet, F., Elosaily, H., Hussein, D. K., El-Shiekh, R. A., A’aqoulah, A., Yousef, E. M., ... and El-Dessouki, A. M. (2025). Bridging Gaps in Migraine Management: A Comprehensive Review of Conventional Treatments, Natural Supplements, Complementary Therapies, and Lifestyle Modifications. Pharmaceuticals, 18(2), 139.
16.    Debnath, A., Majumder, S., Chowdhury, B. D., Sarkar, A., Das, S. K., and Debnath, B. (2024). Tree species diversity and population dynamics and regeneration status in the tropical forest of Tripura: confluence of indo-burmese biodiversity hotspot. Vegetos, 1-11.
17.    Janardhana, K., Sowmya Dhanalakshmi, C., Thilagham, K. T., Chinnaiyan, S. K., Jai Shanker Pillai, H. P., Sathish, T., ... and De Poures, M. V. (2024). Experimental investigation on utilization of Sesbania grandiflora residues through thermochemical conversion process for the production of value-added chemicals and biofuels. Scientific Reports, 14(1), 7283.
18.    Lachungpa, O., Behera, M. C., Nayak, H., and Mohanty, T. L. (2020). Impact of fly ash on germination and initial seedling growth of vegetable hummingbird [Sesbania grandiflora (L.) Poiret]. E-planet, 18, 47-54.
19.    Bunma, S., and Balslev, H. (2019). A review of the economic botany of Sesbania (Leguminosae). The Botanical Review, 85, 185-251.
20.    Wagh, V. D., Wagh, K. V., Tandale, Y. N., & Salve, S. A. (2009). Phytochemical, pharmacological and phytopharmaceutics aspects of Sesbania grandiflora (Hadga): A review. Journal of Pharmacy Research, 2(5), 889-892.
21.    Roy, A., Bhoumik, D., Sahu, R. K., and Dwivedi, J. (2014). Phytochemical screening and antioxidant activity of Sesbania grandiflora leaves extracts. Asian Journal of Research in Pharmaceutical Science, 4(1), 16-21.
22.    Mokhtar, F. A., Ahmed, M., Al Dhanhani, A. S., Elbehairi, S. E. I., Alfaifi, M. Y., Shati, A. A., and Fakhry, A. M. (2025). Distribution, Phytochemical Insights, and Cytotoxic Potential of the Sesbania Genus: A Comprehensive Review of Sesbania grandiflora, Sesbania sesban, and Sesbania cannabina. Pharmaceuticals, 18(1), 64.
23.    Arfan, N., Julie, A., Mohiuddin, A., Khan, S., and Labu, Z. (2016). Medicinal properties of the sesbania grandiflora leaves. Ibnosina Journal of Medicine and Biomedical Sciences, 8(06), 271-277.
24.    Singh, S., and Srivastava, M. (2024). Phytochemical investigation and in-vitro antioxidant activity of Sesbania sesban and Sesbania grandiflora seeds. National Academy Science Letters, 47(1), 79-85.
25.    Vinothini, K., Devi, M. S., Shalini, V., Sekar, S., Semwal, R. B., Arjun, P., and Semwal, D. K. (2017). In vitro micropropagation, total phenolic content and comparative antioxidant activity of different extracts of Sesbania grandiflora (L.) Pers. Current Science, 1142-1147.
26.    Loganayaki, N., Suganya, N., and Manian, S. (2012). Evaluation of edible flowers of agathi (Sesbania grandiflora L. Fabaceae) for in vivo anti-inflammatory and analgesic, and in vitro antioxidant potential. Food science and biotechnology, 21, 509-517.
27.    Kale, I., Khan, M. A., Irfan, Y., and Veerana, G. A. (2012). Hepatoprotective potential of ethanolic and aqueous extract of flowers of Sesbania grandiflora (Linn) induced by CCl4. Asian Pacific Journal of Tropical Biomedicine, 2(2), S670-S679.
28.    Krishnakanth, K., Kumar, P., Neeraja, K., and Cheekavolu, C. (2017). Effect of Sesbania grandiflora Linn leaf extracts on diuresis in wistar rats. Int J Basic Clin Pharmacol, 6(6), 1305.
29.    Naik, H. V., Chavan, N., Deshmukh, H. A., Chaskar, P. K., and More, N. S. (2012). Study of antiulcer activity of leaves of Sesbania grandiflora Linn. (Fabaceae). Research Journal of Pharmacognosy and Phytochemistry, 4(6), 322-325.
30.    Doddola, S., Pasupulati, H., Koganti, B., and Prasad, K. V. (2008). Evaluation of Sesbania grandiflora for antiurolithiatic and antioxidant properties. Journal of natural medicines, 62, 300-307.
31.    Ansil, P. N., Soumya, S., and Shafna, S. (2022). Sesbania grandiflora: A Potential Source of Phytopharmaceuticals. AkiNik Publications 169, C-11, Sector-3, Rohini, Delhi-110085, India.
32.    Jaichand, J., Sabu, K. K., and Iyer, T. V. (2024). Cytotoxicity Studies and Antiviral Activity of Sesbania grandiflora. Research Journal of Pharmacy and Technology, 17(6), 2839-2845.
33.    Doddola, S., Pasupulati, H., Koganti, B., and Prasad, K. V. (2008). Evaluation of Sesbania grandiflora for antiurolithiatic and antioxidant properties. Journal of natural medicines, 62, 300-307.
34.    Arunabha, M., and Satish, N. (2014). Evaluation of immunomodulatory activity of Sesbania grandiflora flowers extract in mice. Indonesian journal of Pharmacy, 25(4), 277.
35.    Ramasubbu, K., and Rajeswari, V. D. (2024). Green Synthesising ZnO Nanoparticle Using Sesbania grandiflora and Their Evaluation of Anti-diabetic Anti-advanced Glycation End Products and Cytotoxic Effects. Applied Biochemistry and Biotechnology, 196(5), 2652-2672.
36.    Karthikeyan, P., Suresh, V., Suresh, A., Bright, J. A., Velan, S. S., and Ganesan, A. (2011). Wound healing activity of Sesbania grandiflora (L.) poir. Bark. Int J Pharm Res Dev, 3, 87-93.
37.    Laladhas, K. P., Cheriyan, V. T., Puliappadamba, V. T., Bava, S. V., Unnithan, R. G., Vijayammal, P. L., and Anto, R. J. (2010). A novel protein fraction from Sesbania grandiflora shows potential anticancer and chemopreventive efficacy, in vitro and in vivo. Journal of cellular and molecular medicine, 14(3), 636-646.
38.    Panda, D., Behera, R. K., Behera, P. K., Padhi, S. K., and Nayak, J. K. (2024). Nutritional and nutraceutical potential of underutilised wild flowers used by tribal people of Koraput for Health Benefit. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences, 94(1), 201-207.
39.    Maurya, A. K., and Sidqqui, N. A. (2022). Phytochemical evaluation and antihyperglycemic, cardio protective and antihyperlipidemic activity of sesebania grandiflora flower. NeuroQuantology, 20(6), 9580-9588.
40.    Ansil, P. N., Soumya, S., and Shafna, S. (2022). Sesbania grandiflora: A Potential Source of Phytopharmaceuticals. AkiNik Publications 169, C-11, Sector-3, Rohini, Delhi-110085, India.
41.    Ravisankar, P., Hundia, A., Sindhura, J., Rani, B. S., and Sai, P. (2015). Migraine-A comprehensive review. Journal of Pharmaceutical Research, 5(10).
42.    Dodick, D. W. (2018). A phase‐by‐phase review of migraine pathophysiology. Headache: the journal of head and face pain, 58, 4-16.
43.    Charles, A. (2018). The pathophysiology of migraine: implications for clinical management. The Lancet Neurology, 17(2), 174-182.
44.    Yeh, P. K., An, Y. C., Hung, K. S., and Yang, F. C. (2024). Influences of genetic and environmental factors on chronic migraine: a narrative review. Current Pain and Headache Reports, 28(4), 169-180.
45.    Eikermann-Haerter, K., and Ayata, C. (2010). Cortical spreading depression and migraine. Current neurology and neuroscience reports, 10, 167-173.
46.    Noseda, R., and Burstein, R. (2013). Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain, 154, S44-S53.
47.    Silberstein, S. D. (2004). Migraine pathophysiology and its clinical implications. Cephalalgia, 24(2_suppl), 2-7.
48.    Hamel, E., and Currents, H. (2007). Serotonin and migraine: biology and clinical implications. Cephalalgia, 27(11), 1293-1300.
49.    de Tommaso, M., and Sciruicchio, V. (2016). Migraine and central sensitization: clinical features, main comorbidities and therapeutic perspectives. Current rheumatology reviews, 12(2), 113-126.
50.    Gupta, S., Mehrotra, S., Villalón, C. M., Perusquía, M., Saxena, P. R., and MaassenVanDenBrink, A. (2007). Potential role of female sex hormones in the pathophysiology of migraine. Pharmacology & therapeutics, 113(2), 321-340.
51.    May, A., and Burstein, R. (2019). Hypothalamic regulation of headache and migraine. Cephalalgia, 39(13), 1710-1719.
52.    Karale, P. A., Karale, M. A., Dharashive, V., Ladde, S., and Yelam, V. (2018). Phytochemical screening and in-vivo anti-inflammatory potential of Sesbania grandiflora. European Journal of Biomedical and Pharmaceutical Sciences, 5(3), 343-347.
53.    Sutradhar, K. B., and Choudhury, N. F. (2012). Analgesic and CNS depressant activity of the crude extract of Sesbania grandiflora. International Current Pharmaceutical Journal, 1(3), 56-61.
54.    Sulasmi, S., ASTIRIN, O. P., and WIDIYANI, T. (2020). The most active fraction of red turi flowers (Sesbania grandiflora) on the cytotoxic activity of HepG2 cells. Nusantara Bioscience, 12(1).
55.    Singh, P., Kumar, A., and Singh, A. K. (2022). South Indian Medicinal Herb: An Extensive Comparison of the Neuroprotective Activity. In Indopathy for Neuroprotection: Recent Advances (pp. 168-185). Bentham Science Publishers.
56.    Maurya, A. K., and Sidqqui, N. A. (2022). Phytochemical evaluation and antihyperglycemic, cardio protective and antihyperlipidemic activity of sesebania grandiflora flower. NeuroQuantology, 20(6), 9580-9588.
57.    Buzzi, M. G., and Moskowitz, M. A. (1992). The trigemino-vascular system and migraine. Pathol Biol (Paris), 40(4), 313-317.
58.    Scott, M. B., Styring, A. K., and McCullagh, J. S. (2022). Polyphenols: bioavailability, microbiome interactions and cellular effects on health in humans and animals. Pathogens, 11(7), 770. 

Recomonded Articles:

Author(s): Amit Roy, Pushpa Prasad, Nirmala Gupta

DOI:         Access: Open Access Read More

Author(s): A. K. Meena, Jyoti Meena, Ankush Jadhav, M. M. Padhi

DOI:         Access: Open Access Read More

Author(s): Chaudhari R. D, Girase P. R, Suryawanshi H. P, Pawar S. P

DOI: 10.5958/2231-5713.2018.00025.9         Access: Open Access Read More

Author(s): Wajid Ahmad, Jaza Quazi, Reshma Khan, Nadeem Ahmad, Nawed Ansari

DOI: 10.52711/2231-5713.2022.00023         Access: Open Access Read More

Author(s): Shweta Gautam, Priya Singh, Yogesh Shivhare

DOI:         Access: Open Access Read More

Author(s): Rutuja Saurabh Shah

DOI: 10.52711/2231-5713.2021.00035         Access: Open Access Read More

Author(s): Beedha. Saraswathi, Dr. T. Satyanarayana, K. Mounika, G. Swathi , K. Sravika, M. Mohan Krishna

DOI: 10.5958/2231-5713.2018.00004.1         Access: Open Access Read More

Author(s): Sushil D. Patil, Mukul J. Gupta, Kaustubh S. Kote, Mr. Rajendran R

DOI: 10.5958/2231-5713.2019.00039.4         Access: Open Access Read More

Author(s): Swati Siddheshwar Londhe, Mangesh Gautam Bhosale, Amol Arun Joshi

DOI: 10.5958/2231-5713.2020.00041.0         Access: Open Access Read More

Author(s): Shamali Dange, Ravindra Jadhav, Sunayana Vikhe

DOI: 10.52711/2231-5713.2022.00004         Access: Open Access Read More

Author(s): Basavaraj, Someswara Rao B, S.V Kulkarni, Pramod Patil , Chetan Surpur

DOI:         Access: Open Access Read More

Author(s): Goli Venkateshwarlu, Ragya Eslavath, Anasuri Santhosh, Gutha Suma, J.Venkanna, Y.Swetha

DOI:         Access: Open Access Read More

Author(s): V Jhansipriya Marabathuni, M. Bhavani, M. Lavanya, K. Padmaja, N. Madhavi, P. Babu, Ch. M. M. Prasada Rao

DOI: 10.5958/2231-5713.2017.00022.8         Access: Open Access Read More

Author(s): Shital S. Shinde, Girishchandra R. Mandake, Manoj M. Nitalikar

DOI: 10.5958/2231-5713.2018.00039.9         Access: Open Access Read More

Author(s): Debarshi Kar Mahapatra , Ruchi S. Shivhare , Vinod G. Ugale

DOI: 10.5958/2231-5713.2018.00008.9         Access: Open Access Read More

Author(s): AVS Madhu Latha, T Naga Ravikiran, J N Suresh Kumar

DOI: 10.5958/2231-5713.2019.00001.1         Access: Open Access Read More

Author(s): Neha Srivastava, Seema Thakur, Anchal Bajaj, Nikita Sahi

DOI:         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags