Author(s): Shalini, Piyush Sharma, Pooja Chauhan, Poonam, Pranav, Pranav Sharma

Email(s): shalini.davsnr8@gmail.com

DOI: 10.52711/2231-5713.2025.00060   

Address: Shalini*, Piyush Sharma, Pooja Chauhan, Poonam, Pranav, Pranav Sharma
Department of Pharmaceutical Chemistry, Abhilashi College of Pharmacy, Ner-Chowk, Mandi, H.P. 175008.
*Corresponding Author

Published In:   Volume - 15,      Issue - 4,     Year - 2025


ABSTRACT:
For over-the-counter (OTC) formulations to be safe, effective, and compliant with regulations, the active pharmaceutical ingredients (APIs) must be precisely quantified. UV spectrophotometry is unique among analytical methods since it is easy to use, reasonably priced, and appropriate for regular quality control. The principles and use of the calibration curve approach in UV spectrophotometry for the quantitative assay of vitamin C, aspirin, and paracetamol are examined in this paper. It explores the theoretical underpinnings, sample preparation techniques, validation procedures, and comparisons of commercial formulations. The method's benefits and drawbacks are thoroughly examined, as are upcoming developments in pharmaceutical analysis, including automation, chemometrics, and green chemistry techniques. This thorough review emphasizes the reliability and usefulness of UV spectrophotometric analysis in pharmaceutical quality control, particularly for popular over-the-counter drugs.


Cite this article:
Shalini, Piyush Sharma, Pooja Chauhan, Poonam, Pranav, Pranav Sharma. Analytical Perspectives on UV Spectrophotometric Assay of Paracetamol, Aspirin, and Vitamin C using Calibration Curve Method: Principles, Practices, and Comparative Evaluation. Asian Journal of Pharmacy and Technology. 2025; 15(4):421-5. doi: 10.52711/2231-5713.2025.00060

Cite(Electronic):
Shalini, Piyush Sharma, Pooja Chauhan, Poonam, Pranav, Pranav Sharma. Analytical Perspectives on UV Spectrophotometric Assay of Paracetamol, Aspirin, and Vitamin C using Calibration Curve Method: Principles, Practices, and Comparative Evaluation. Asian Journal of Pharmacy and Technology. 2025; 15(4):421-5. doi: 10.52711/2231-5713.2025.00060   Available on: https://ajptonline.com/AbstractView.aspx?PID=2025-15-4-13


11. REFERENCES:
1.    Sweetman SC. Martindale: The Complete Drug Reference. 36th ed. Pharmaceutical Press, 2009.
2.    Rang HP et al. Rang and Dale’s Pharmacology. 9th ed. Elsevier, 2020.
3.    British Pharmacopoeia 2023. UK Medicines and Healthcare products Regulatory Agency.
4.    FDA. Analytical Procedures and Methods Validation, Guidance for Industry. 2015.
5.    ICH Q2(R1). Validation of Analytical Procedures: Text and Methodology. 2005.
6.    Beckett AH, Stenlake JB. Practical Pharmaceutical Chemistry. Vol. 2, 4th ed. CBS Publishers, 2005.
7.    Skoog DA et al. Principles of Instrumental Analysis. 6th ed. Cengage Learning. 2007.
8.    Harvey D. Modern Analytical Chemistry. McGraw-Hill. 2000.
9.    Sharma BK. Instrumental Methods of Chemical Analysis. Krishna Prakashan, 2006.
10.    Ahuja S, Scypinski S. Handbook of Modern Pharmaceutical Analysis. Academic Press, 2021.
11.    Indian Pharmacopoeia 2022. Indian Pharmacopoeia Commission.
12.    USP 2023. United States Pharmacopeia-National Formulary.
13.    European Pharmacopoeia 2023. Council of Europe.
14.    Snyder LR et al. Introduction to Modern Liquid Chromatography. 3rd ed. Wiley. 2010.
15.    Niazi SK. Handbook of Pharmaceutical Manufacturing Formulations. CRC Press. 2019.
16.    Ali J et al. UV Spectrophotometric Method for Estimation of Paracetamol. Indian Drugs. 2018.
17.    Jain DK et al. Development and Validation of Spectrophotometric Methods for Aspirin. IJPSR. 2019.
18.    Ranjith A et al. Simultaneous Estimation of Vitamin C and Paracetamol. J Pharm Sci. 2020.
19.    Kumar A et al. Analytical Method Validation Parameters. JAPS, 2021.
20.    Bhutkar M et al. UV-Spectroscopic Assay for Combined Dosage Forms. Asian J Pharm, 2021.
21.    Sharma K et al. Validation of UV Method for Aspirin. Int J PharmTech Res. 2022.
22.    Desai B et al. Method Development Using Beer-Lambert Law. J Anal Chem. 2020.
23.    Singh A et al. Pharmaceutical Quality by Design: A Review. IJPER. 2023.
24.    Vardhan A et al. Chemometrics in Pharmaceutical Analysis. J Pharm Biomed Anal. 2023.
25.    Gaikwad A et al. Green Analytical Chemistry Techniques. Green Chem Lett Rev. 2023.

Recomonded Articles:

Author(s): Hafsa, Asfa, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5713.2017.00001.0         Access: Open Access Read More

Author(s): Juveriya Fatima, Saniya Khan, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5713.2017.00009.5         Access: Open Access Read More

Author(s): Manohar D. Kengar, Rohit S. Howal, Dattatray B. Aundhakar, Amit V. Nikam, Priyajit S. Hasabe

DOI: 10.5958/2231-5713.2019.00010.2         Access: Open Access Read More

Author(s): Avinash B. Thalkari, Pawan N. Karwa, Chandrakant S. Gawli

DOI: 10.5958/2231-5713.2018.00017.X         Access: Open Access Read More

Author(s): Safa Mohammed Sadiq, Amtul Kareem, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5713.2017.00002.2         Access: Open Access Read More

Author(s): Abhishek K. Sah, Manmohan Singh Jangdey, Sanjay J. Daharwal

DOI:         Access: Open Access Read More

Author(s): Amit Roy, Pushpa Prasad, Nirmala Gupta

DOI:         Access: Open Access Read More

Author(s): Abhijit Ray

DOI:         Access: Open Access Read More

Author(s): Vinay Bhagat, Vivek Karel, Shivani Chaudhary, Kapil Kumar Verma

DOI: 10.52711/2231-5713.2024.00008         Access: Open Access Read More

Author(s): Brijesh Kumar Duvey, Rohit Goyel, Bharat Parashar, Denesh Verma, Hitesh Dhameja, Dharmesh Sharma

DOI:         Access: Open Access Read More

Author(s): Sanjay Kshirsagar, Manisha Choudhari, Reshmi Sathyan, Shruti Dhore

DOI: 10.5958/2231-5713.2019.00024.2         Access: Open Access Read More

Author(s): Vikranti W. Koli, Manohar D. Kengar, Amruta B. Kamble, Suraj B. Kumbhar, Rahul P. Jadhav

DOI: 10.5958/2231-5713.2019.00022.9         Access: Open Access Read More

Author(s): Chinmaya Keshari Sahoo, K. Satyanarayana, D. Venkata Ramana, Kanhu Charan Panda

DOI: 10.5958/2231-5713.2017.00034.4         Access: Open Access Read More

Author(s): Mounika P Siridevi, Hemant T Kumar, Srinivasa Y Rao, Vara Prasad K Rao

DOI: 10.5958/2231-5713.2019.00035.7         Access: Open Access Read More

Author(s): Prema. V, Ishwaryalakshmi. K, Subhashini. S, Kavisri. M, Kishore. P

DOI: 10.52711/2231-5713.2024.00006         Access: Open Access Read More

Author(s): Indrajeet V. Mane, Abhishek S. Pujari, Nitin A. Gaikwad, Rajeshwar V. Chavan, Ganesh B. Vambhurkar

DOI: 10.5958/2231-5713.2018.00030.2         Access: Open Access Read More

Author(s): Abhishek S. Pujari, Nitin A. Gaikwad, Indrajeet V. Mane, Ganesh B. Vambhurkar, Pravin P. Honmane

DOI: 10.5958/2231-5713.2018.00019.3         Access: Open Access Read More

Author(s): Poonam R. Songire, Smita S. Aher, R. B. Saudagar

DOI: 10.5958/2231-5713.2015.00031.8         Access: Open Access Read More

Author(s): Abdul Saleem Mohammad, Swetha Devidi, Nikhat Fatima, Humera Badar, Syeda Saba Sulthana, Mohammad Akthar Sulthana, Nuha Rasheed

DOI:         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags