Author(s): V Jhansipriya Marabathuni, M. Bhavani, M. Lavanya, K. Padmaja, N. Madhavi, P. Babu, Ch. M. M. Prasada Rao

Email(s): jhansi.priya356@gmail.com

DOI: 10.5958/2231-5713.2017.00022.8   

Address: V Jhansipriya Marabathuni1*, M. Bhavani1, M. Lavanya1, K. Padmaja1, N. Madhavi1, P. Babu1, Ch. M. M. Prasada Rao2
1Associate Professor, Bellamkonda Institute of Technology and Sciences, Podili
1Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili.
2Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2017


ABSTRACT:
Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain. Carbamazepine is used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy. Carbamazepine is also used to treat bipolar disorder. Due to sudden onset of attack, it is necessary to formulate antiepileptics into such a delivery system, which provide immediate relief. Hence, the present investigation was undertaken with a view to develop mouth-dissolving tablets of Carbamazepine, which offers a new range of product having desired characteristics and intended benefits. In this study, the mouth dissolving tablets were prepared using two different technologies, direct compression method and solid dispersion technology. Tablets produced by direct compression method contain crospovidone as a super disintegrant and sorbitol as a sweetener. Solid dispersions of Carbamazepine with polyvinylpyrrolidone K-30 and polyethylene glycol 6000 in different weight ratios were prepared with a view to increase its water solubility. Carbamazepine solid dispersions with polyvinylpyrrolidone K-30 in 1:2 ratios of drug: carrier showed maximum drug release and hence, compressed along with other excipients into mouth dissolving tablet. The results compared for both the technologies showed that the Carbamazepine tablets prepared using solid dispersion technology was found to have good technological properties and satisfying and reproducible drug dissolution profiles. Moreover, the drug release was found to be comparable to the marketed dispersible tablet.


Cite this article:
V Jhansipriya Marabathuni, M. Bhavani, M. Lavanya, K. Padmaja, N. Madhavi, P. Babu, Ch. M. M. Prasada Rao. Formulation and evaluation of mouth dissolving Tablets of carbamazepine. Asian J. Pharm. Tech. 2017; 7 (3): 137-143. doi: 10.5958/2231-5713.2017.00022.8


Recomonded Articles:

Author(s): Manohar D. Kengar, Rohit S. Howal, Dattatray B. Aundhakar, Amit V. Nikam, Priyajit S. Hasabe

DOI: 10.5958/2231-5713.2019.00010.2         Access: Closed Access Read More

Author(s): Beedha. Saraswathi, Dr. T. Satyanarayana, K. Mounika, G. Swathi , K. Sravika, M. Mohan Krishna

DOI: 10.5958/2231-5713.2018.00004.1         Access: Open Access Read More

Author(s): Anju govind, Manjunath B Menden, Ravikumar, Simila1, Mercy, Narayana Swamy VB

DOI: 10.5958/2231-5713.2016.00013.1         Access: Open Access Read More

Author(s): Nirmala Rangu, B. Chaitanya Kumari, Ganesh Akula, A Jaswanth

DOI: 10.5958/2231-5713.2018.00001.6         Access: Open Access Read More

Author(s): Girishchandra R. Mandake, Shital S. Shinde, Omkar A. Patil, Manojkumar M. Nitalikar

DOI: 10.5958/2231-5713.2018.00040.5         Access: Closed Access Read More

Author(s): Rohan Patil, Neha Patil, Aniket Patil , S. J. Shid, V.N. Dange, C.S. Magdum, S.K. Mohite

DOI: 10.5958/2231-5713.2016.00026.X         Access: Open Access Read More

Author(s): Dhiraj A. Khairnar, Avinash B. Darekar, Ravindra B. Saudagar

DOI: 10.5958/2231-5713.2016.00018.0         Access: Open Access Read More

Author(s): Neha Srivastava, Seema Thakur, Anchal Bajaj, Nikita Sahi

DOI:         Access: Open Access Read More

Author(s): Basavaraj, Someswara Rao B, S.V Kulkarni, Pramod Patil , Chetan Surpur

DOI:         Access: Open Access Read More

Author(s): Pratiksha Sonawale, Amol Patil, Asmit Kamble, Mangesh Bhutkar

DOI:         Access: Open Access Read More

Author(s): Vaishali B. Morade, Vandana R. Daga, Dr. Prashant R. Malpure

DOI: DOI: 10.5958/2231-5713.2018.00006.5         Access: Open Access Read More

Author(s): Ulhas Balkrishna Hadkar, Poonam Rajesh Advani, Radhika Kishore Raheja

DOI: 10.5958/2231-5713.2017.00017.4         Access: Open Access Read More

Author(s): K. Hemalatha, D. Niranjan Raj, M. Fousia Begam, Sharanya. V.K., K. Girija

DOI: 10.5958/2231-5713.2017.00019.8         Access: Open Access Read More

Author(s): Dange YD, Honmane SM, Patil PA, Gaikwad UT, Jadge DR

DOI: 10.5958/2231-5713.2017.00010.1         Access: Open Access Read More

Author(s): D. M. Shinkar, A. N. Patil , R. B. Saudagar

DOI: 10.5958/2231-5713.2017.00011.3         Access: Open Access Read More

Author(s): Sarfaraz Md., Arshad Ahmed Khan K., Doddayya H., Reddy S.R. , Udupi R.H.

DOI:         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags