The aim of the present research work was to investigate the potential of emulgel in enhancing the topical delivery of Turmeric. Emulgel formulations of Turmeric were prepared using Carbopol 934 as a gelling agent. The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the prepared emulgel was investigated using. The main purpose of this research was to design to formulate and evaluate a topical gellified emulsions (Emulgel) of Turmeric by using high molecular weight water soluble polymer Carbapol 934. This Carbapol possesses very high viscosity, transparency, film forming properties at low concentration and reported to be useful in formation of gel with an objective to increase transparency and spreadability. All the prepared emulgel showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. The influence of the type of gelling agent on the drug release from the prepared emulgels was investigated and carbopol 934 showed good results not only in the drug release but also in physical evaluation parameters. From the drug release studies, F3 formulation showed 90.05% drug release in 6 h with good clarity and physical appearance and viscosity 2250cps.Stability studies showed that the physical appearance, rheological study, in vitro drug release, and anti-inflammatory activity in all the prepared emulgel remained unchanged upon storage for 3 months. It was finally concluded that the formulation F3 with 1%w/w Carbopol 934 was found to be more promising formulations as it shows better physicochemical characteristics and antiinflammatory activity compared to other formulations.
Cite this article:
Rutuja Saurabh Shah. Formulation and Evaluation of Turmeric Emulgel. Asian Journal of Pharmacy and Technology. 2021; 11(3):213-9. doi: 10.52711/2231-5713.2021.00035
Rutuja Saurabh Shah. Formulation and Evaluation of Turmeric Emulgel. Asian Journal of Pharmacy and Technology. 2021; 11(3):213-9. doi: 10.52711/2231-5713.2021.00035 Available on: https://ajptonline.com/AbstractView.aspx?PID=2021-11-3-5
1. Apisariyakul A, Vanittanakomm N, and Buddhasukh D: Antifungal activity of turmeric oil extracted from Curcuma longa (Zingiberaceae). J. Ethnopharmacol.1995; 49:163–169.
2. Kumar L, Verma R: In vitro evaluation of topical gel prepared using natural polymer. Int J drug deli 2010;2: 58-63.
3. Singla V, Saini S, Joshi B and Rana A: Emulgel: A new platform for topical drug delivery. International Journal of Pharma and Bio Sciences 2012;3(1):485-98.
4. Hosny KM, Rambo SM, Al-Zahrani MM, Al-Subhi SM and Fahmy UA: Ketoprofenemulgel: preparation, characterization, and pharmacodynamic evaluation. Int J Pharm Sci Rev Res. 2013;20(2):306-10.
5. Shah C. and Shah D: Design and Optimization of Fluconazole Microsponges Containing Ethyl Cellulose for Topical Delivery System Using Quality by Design Approach, Pharma Science Monitor 2014;5(3): 95-133.
6. Khunt DM., Mishra AD.and Shah Dr: Formulation design and of piroxicamemulgel. Int J PharmTec Res. 2012; 4(3): 1332- 1344.
7. Panwar AS., Upadhyay N., Bairagi M., Gujar S., DarwhekarGN.andJain DK: Emulgel: A review. Asian J Pharm Life Sci. 2011; 1(3):333-343.
8. International Journal of Trends in Pharmacy and Life SciencesVol. 1, Issue: 4, 2015: 487-501.
9. Ana ML, Elizangela A, Andre LMC, Ruth RS, Miracy MA, and Almir GW.: Development of topical formulation: anti-inflammatory study of a selected formulation. AAPS Pharm Sci Tech. 2008; 9(1): 163-168.
10. Jain A, Gautam SP, Gupta Y, Khambete H, and Jain S.: Development andcharacterization of ketoconazole emulgel for topical drug delivery. Der Pharmacia Sinica 2010; 11(3):221-231.
11. Yassin GE.: Formulation and evaluation of optimized clotrimazoleemulgel formulations. British Journal of Pharmaceutical Research. 2014;4(9):1014.
12. Baibhav J, Gurupreet S, Rana AC, Seema S and Vikas S: Emulgel: a comprehensive review on the recent advances in topical drug delivery. Int Res J Pharm. 2011; 2(11): 66-70.
13. Gupta A, Mishra AK, Singh AK, Gupta V, and Bansal P.: Formulation and evaluation of topical gel of diclofenac sodium using different polymers. Drug Invention Today 2010; 2:250-253.
14. Hosny KM, Rambo SM., Al-ZahraniMM., Al-Subhi SM., and Fahmy UA.: Ketoprofenemulgel: preparation, characterization, and pharmacodynamic evaluation. Int Pharm Sci Rev Res. 2013; 20(2): 306-310.
15. Lachman, L.; Lieberman, HA: The Theory and Practice of Industrial Pharmacy. Varghese Publishing house, 3rd Edition1990.
16. Sanjay, Jain BD, Padsalg A, Patel K and Mokale V: Formulation, development and evaluation of Fluconazole gel in various polymer bases, Asi. J. Pharm., 2007; 1: 63-68.
17. Singh R, Parpani S, Narke R and Chavan R: Emulgel: A Recent Approach for Topical Drug Delivery System. Asian Journal of Pharmaceutical Research and Development Vol. 2014;2(2):112-23.
18. Khuller R, Murthy P, Nath L and Choudhury P: kinetic modeling of drug release from controlled drug delivery system. ActaPoloniae Pharmaceutical Drug Research. 2010; 67:217-223.
19. Bhatt P and Gnanaranjan G: Emulgel- A Novel Formulation Approach for Topical Delivery of Hydrophobic Drugs. International Research Journal of Pharmacy. 2013; 4(2):12-16.