Author(s):
Pinki Verma, Saheb Kuila, Subhendu Kumar Jana, Animesh Deb, Bipul Das
Email(s):
vermapinki05@gmail.com
DOI:
10.52711/2231-5713.2026.00033 
Address:
Pinki Verma1*, Saheb Kuila2, Subhendu Kumar Jana3, Animesh Deb4, Bipul Das5
1Associate Professor, Department of Pharmacology, Aditya Bangalore Institute of Pharmacy Education & Research, Yelahanka, Bengaluru, Karnataka, India.
2Research Scholar, Department of Pharmacology, Aditya Bangalore Institute of Pharmacy Education & Research, Yelahanka, Bengaluru, Karnataka, India.
3Research Scholar, Department of Pharmacology, Aditya Bangalore Institute of Pharmacy Education & Research, Yelahanka, Bengaluru, Karnataka, India.
4Research Scholar, Department of Pharmacology, Aditya Bangalore Institute of Pharmacy Education & Research, Yelahanka, Bengaluru, Karnataka, India.
5Research Scholar, Department of Pharmacology, Aditya Bangalore Institute of Pharmacy Education & Research, Yelahanka, Bengaluru, Karnataka, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2026
ABSTRACT:
Background: Helminth infections continue to be a significant public health concern worldwide, especially in tropical nations, leading to nutritional deficiencies, decreased work efficiency, and increased disease burden. The emergence of resistance to commonly used anthelmintic drugs has created an urgent need for new and effective plant-based therapeutic alternatives. Aim: This study aimed to investigate the anthelmintic efficacy and phytochemical profile of ethanolic extracts of Saraca indica (Roxb.) and Ocimum sanctum, utilizing Gas Chromatography–Mass Spectrometry (GC-MS). Methods: Ethanolic extracts of Saraca indica and Ocimum sanctum were obtained via Soxhlet extraction. Phytochemical constituents of Saraca indica were characterized through GC-MS analysis. Anthelmintic activity was evaluated using adult Pheretima posthuma at concentrations of 50 and 100mg/mL, and the results were compared with the standard drug albendazole (20mg/mL) by measuring paralysis and mortality times. Results: GC-MS profiling of Saraca indica revealed 52 bioactive compounds, including phenols, flavonoids, alkaloids, terpenoids, saponins, and tannins. Both extracts showed marked dose-dependent anthelmintic activity. The combined ethanolic extract of both plants at 100mg/mL caused rapid paralysis (5.3±0.12min) and death (9.5±0.26min), demonstrating stronger effectiveness than albendazole. Conclusion: The findings confirm that ethanolic extracts of Saraca indica and Ocimum sanctum exhibit potent anthelmintic action, likely due to their rich phytochemical content. These medicinal plants represent promising candidates for the development of safe and effective herbal anthelmintic formulations, supporting further research on bioactive compound isolation and formulation design.
Cite this article:
Pinki Verma, Saheb Kuila, Subhendu Kumar Jana, Animesh Deb, Bipul Das. GC-MS Profiling and Evaluation of Anthelmintic Activity of Saraca indica Roxb and Ocimum sanctum Extracts on Pheretima posthuma. Asian Journal of Pharmacy and Technology. 2026; 16(3):235-0. doi: 10.52711/2231-5713.2026.00033
Cite(Electronic):
Pinki Verma, Saheb Kuila, Subhendu Kumar Jana, Animesh Deb, Bipul Das. GC-MS Profiling and Evaluation of Anthelmintic Activity of Saraca indica Roxb and Ocimum sanctum Extracts on Pheretima posthuma. Asian Journal of Pharmacy and Technology. 2026; 16(3):235-0. doi: 10.52711/2231-5713.2026.00033 Available on: https://ajptonline.com/AbstractView.aspx?PID=2026-16-3-3
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