Formulation and Evaluation of Mouth Dissolving Tablets of Zolmitriptan

Vaishali B. Morade; Vandana R. Daga; Dr. Prashant R. Malpure

doi:DOI:  10.5958/2231-5713.2018.00006.5

Asian Journal of Pharmacy and Technology

ISSN

2231-5713 (Online)
2231-5705 (Print)

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Formulation and Evaluation of Mouth Dissolving Tablets of Zolmitriptan

Author(s): Vaishali B. Morade, Vandana R. Daga, Dr. Prashant R. Malpure

Email(s): vaishali.morade@gmail.com

DOI: DOI: 10.5958/2231-5713.2018.00006.5

Address: Vaishali B. Morade*, Vandana R. Daga, Dr. Prashant R. Malpure Department of Pharmaceutics, S.G.S.S’s Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Kalwan.
*Corresponding Author

Published In: Volume - 8, Issue - 1, Year - 2018

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ABSTRACT:
The objective of present study was to formulate mouth dissolving tablets of Zolmitriptan. Zolmitriptan is a 5-HT receptor agonist. It is used in the treatment of migraine. Six different formulations of Zolmitriptan mouth dissolving tablets were prepared by using direct compression technique by using different concentrations of AC-Di-Sol, Avicel pH 101 and strlac. Tablets were evaluated for different precompression and post compression parameters of tablets were carried out and the results satisfies according to the pharmacopoeia specifications. Other parameters such as drug-excipients compatibility were also evaluated through IR and DSC study.IR and DSC studies revelled that there is no interaction between drug and different excipients used in formulation. Formulation F6 was selected as optimised formulation showing better dissolution results at 35 minutes. Zolmitriptan, mouth dissolving tablets, Ac-Di-Sol, Antimigraine.

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Cite this article:
Vaishali B. Morade, Vandana R. Daga, Dr. Prashant R. Malpure. Formulation and Evaluation of Mouth Dissolving Tablets of Zolmitriptan. Asian J. Pharm. Tech. 2018; 8 (1): 35-42. doi: DOI: 10.5958/2231-5713.2018.00006.5

Cite(Electronic):
Vaishali B. Morade, Vandana R. Daga, Dr. Prashant R. Malpure. Formulation and Evaluation of Mouth Dissolving Tablets of Zolmitriptan. Asian J. Pharm. Tech. 2018; 8 (1): 35-42. doi: DOI: 10.5958/2231-5713.2018.00006.5 Available on: https://ajptonline.com/AbstractView.aspx?PID=2018-8-1-6

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Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

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DOI: 10.5958/2231–5713