Author(s): Rohankumar R. Chavan, Sheela S. Thorat, Aishwarya R Thoke

Email(s): rohankumar3102@gmail.com

DOI: 10.5958/2231-5713.2019.00031.X   

Address: Rohankumar R. Chavan*, Sheela S. Thorat, Aishwarya R Thoke
1Dept of Pharmaceutical Chemistry, Adarsh College of Pharmacy, Vita, Dist – Sangli, Maharashtra, India – 416311
2Dept of Pharmaceutical Chemistry, Adarsh College of Pharmacy, Vita, Dist – Sangli, Maharashtra, India – 416311
*Corresponding Author

Published In:   Volume - 9,      Issue - 3,     Year - 2019


ABSTRACT:
Spironolactone is most commonly used anti-diuretic agent in clinical practices. Spironolactone site of action is intracellular aldosterone receptors in the distal tubule cells. This increases the excretion of water and sodium and decreases the excretion of potassium. The degradation is most commonly found problem in most of products. The ICH guidelines states the parameters for forced degradation studies which includes the Acid/base stress testing, heat or humidity, photo degradation, pH variation. According to WHO monographic specifications the official assay limit of content should NLT 95% and NMT 105% of the estimated potency. When Spironolactone is subjected to 0.1N HCl and 0.1N NaOH, and heat it shows the increased availability. When exposed to UV light for 30 min the drug shows extremely decreased availability.


Cite this article:
Rohankumar R. Chavan, Sheela S. Thorat, Aishwarya R Thoke. Degradation Study of Spironolactone by UV- Visible Spectrophotometry Method in Bulk Form. Asian J. Pharm. Tech. 2019; 9(3):185-188. doi: 10.5958/2231-5713.2019.00031.X


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DOI: 10.5958/2231–5713 


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