Author(s): AVS Madhu Latha, J N Suresh Kumar, N Sojana, N Mounika, G Priyanka, A Venkatesh

Email(s): satyamadhulatha@gmail.com

DOI: 10.5958/2231-5713.2021.00007.6   

Address: AVS Madhu Latha*, Dr. J N Suresh Kumar*, N Sojana, N Mounika, G Priyanka, A Venkatesh
Department of Pharmaceutics, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 1,     Year - 2021


ABSTRACT:
Emulgel is one of the recent technologies in NDDS used for dual controlled release of emulsion and gel for topical use. The stability of emulsion is increased, when it is incorporated into gel. Clotrimazole is a broad spectrum antifungal agent, also a hydrophobic drug. It is difficult to formulate as topical delivery. So emulgel is one of the best approaches to incorporate hydrophobic drugs. The purpose of the present study was to develop and optimized the Clotrimazole emulgel using polymers like Carbopol 934 and HPMC K4M at different concentrations. The Preformulation studies were conducted by using FTIR studies, the prepared emulgels were evaluated in terms of physical appearance, measurement of pH, viscosity, spreadability, drug content and in vitro diffusion studies. In vitro drug release studies were performed up to 8hrs. Among all formulations F6 shows better releasing property. So F6 was proved as the best formulation among all. F6 containing HPMC K4M polymer in low concentration showed better releasing property when compared to formulations containing Carbopol 934. So it was suggested that the Clotrimazole emulgel have potential advantages when compared to other topical drug delivery systems for incorporating hydrophobic drugs and posses better activity and stability.


Cite this article:
AVS Madhu Latha, J N Suresh Kumar, N Sojana, N Mounika, G Priyanka, A Venkatesh. Design and Optimization of Clotrimazole Emulgel by using various Polymers. Asian J. Pharm. Tech. 2021; 11(1):41-47. doi: 10.5958/2231-5713.2021.00007.6

Cite(Electronic):
AVS Madhu Latha, J N Suresh Kumar, N Sojana, N Mounika, G Priyanka, A Venkatesh. Design and Optimization of Clotrimazole Emulgel by using various Polymers. Asian J. Pharm. Tech. 2021; 11(1):41-47. doi: 10.5958/2231-5713.2021.00007.6   Available on: https://ajptonline.com/AbstractView.aspx?PID=2021-11-1-7


REFERENCE:
1.    Lawrence H. Block. Medicated Topicals, Ch.44 in Remington. In: Lippincott Williams and Wilkins, editors. The science and practice of pharmacy 21th ed. Philadelphia; 2006.
2.    L.Lackman, H. A, Lieberman and J.L.Kanig, Theory and Practice of Industrial Pharmacy, Lea and Fibiger, Philadelphia Latest Edn.
3.    Mohamed MI Topical emulsion- gel composition comprising diclofenac sodium. AAPS Journal 2004; 6(3).
4.    Mohamed MI. Optimization of Cholrphensin emulgel formulation. AAPS Journal. 2004;6:(26).
5.    Rieger MM, Lachmann L, Lieberman HA, Kanig JL. In: Lea and Fibiger, editors. The theory and the practice of industrial pharmacy 3rd ed. Philadelphia; 1986.
6.    Shahin M, Abdel Hady S, Hammad M, Mortada N. Optimized formulation for topical administration of Clotrimazole using pemulen polymeric emulsifier: a conceptual framework. Drug development and industrial pharmacy.2011;37(5):559-568. Accessed 25 June 2010. Available: http://www.ncbi.nlm.nih.gov.pubmed/21128701
7.    Steven P. Gelone. Anti- infectives, Ch. 90 in Remington. In: Lippincott Williams and Wilkins, editors. The science and practice of pharmacy 21 th ed. Philadelphia: Lippincott Williams and Wilkins; 2006.
8.    The Merk Index. In: MaryadeleJ.O, Neil, editor. An encyclopaedia of Chemicals, Drugs and Biologicals 14 the d. NJ, USA: Merck and co; 2006.
9.    Martindale. The complete drug references: Sean C Sweet man, editor. 36th ed. The pharmaceutical press; 2009.
10.    Sunil Kumar Yadav, Manoj kumar Mishra, Anupamaa Tiwari, AshutoshShukla. “Emulgel: a new approach for enhanced topical drug delivery.” Int J Curr Pharma Res 2017; 9(1):15-19.
11.    Date AA, Naik B, and Nagarsenker MS. Novel Drug Delivery Systems: Potential in improving topical delivery of antiacne agents. Skin Pharmacol Physol 19(1):2-16(2006).
12.    Joshi M, Butola BS, Saha K. Advances in topical drug delivery system: micro to nanofibrous structures. J Menisci Nanotechnology 2014; 14:853-67
13.    Tortora, G.J and Anagnodokas, Principles of Anatomy and Physiology, N.P Happer and Row Publishers N.Y.
14.    Ross and Wilson, Anatomy and Physiology in the health and illness.
15.    A.S. Panwar, N. Upadhyay, M. Bairagi, S. Gujar, G.N. Darwhekar, D. K. Jain. “Emulgel: A Review.” Asian J Pharmacy and life Sci 2011; 1(3): 333-343.
16.    Joshi Bhaibav et al; ‘’Clarithromycin Emulgel for topical delivery’’: International Journal of Drug Development and Research 2012: vol. 4 Issue 3. ISSN 0975-9344.
17.    Snehal P. Mulye, et al; ‘’Formulation and Evaluation of Indomethacin Emulgel’’. Der Pharmacia Sinica; 2013, 4(5):31-45.
18.    Joshi Bhaibav et al; ‘’Clarithromycin Emulgel for topical delivery’’: International Journal of Drug Development and Research 2012: vol. 4 Issue 3. ISSN 0975-9344.
19.    Monika Rao et al; ‘’Optimization of Metronidazole Emulgel”. Journal of Pharmaceutics; 2013;2013;501082.
20.    Dalia Abd El Rhman et al; ‘’ Formulation and evaluation of Fluconazole Emulgel”. International Journal of Pharmacy and Pharmaceutical sciences; 2012, 4(5): 176-183.

Recomonded Articles:

Author(s): Manohar D. Kengar, Rohit S. Howal, Dattatray B. Aundhakar, Amit V. Nikam, Priyajit S. Hasabe

DOI: 10.5958/2231-5713.2019.00010.2         Access: Open Access Read More

Author(s): Anuradha A Sawant, S.K. Mohite.

DOI: 10.5958/2231-5713.2015.00014.8         Access: Open Access Read More

Author(s): Nirmala Rangu, B. Chaitanya Kumari, Ganesh Akula, A Jaswanth

DOI: 10.5958/2231-5713.2018.00001.6         Access: Open Access Read More

Author(s): Madan Singh, Prashant Soni, Neeraj Upmanyu , Yogesh Shivhare

DOI:         Access: Open Access Read More

Author(s): K. Vanitha. M. Venkataswamy, Sanam Niharika, Alluri Ramesh

DOI: 10.5958/2231-5713.2018.00011.9         Access: Open Access Read More

Author(s): Jenifer. P, C.P. Balakrishnan, S. Chidambaram Pillai

DOI: 10.5958/2231-5713.2017.00018.6         Access: Open Access Read More

Author(s): Godbole Ajeet Madhukar, Patel Bhautik V, Somnache Sandesh Narayan, Prajapati Ashish R, Yadav Pradeep

DOI: 10.5958/2231-5713.2017.00004.6         Access: Open Access Read More

Author(s): Sarfaraz Md., Arshad Ahmed Khan K., Doddayya H., Reddy S.R. , Udupi R.H.

DOI:         Access: Open Access Read More

Author(s): Sampada V. Kadam, Nilima U. Rane, Chandrakant S. Magdum

DOI: 10.5958/2231-5713.2019.00011.4         Access: Open Access Read More

Author(s): Vaishali B. Morade, Vandana R. Daga, Dr. Prashant R. Malpure

DOI: DOI: 10.5958/2231-5713.2018.00006.5         Access: Open Access Read More

Author(s): Girishchandra R., Mandake, Shital S. Shinde, Vishal Y. Belaskar, Asha M. Jagtap, Ganesh B. Vambhurkar, Manoj M. Nitalikar

DOI: 10.5958/2231-5713.2018.00033.8         Access: Open Access Read More

Author(s): B. Ranga Nayakulu, Nakka Ravi Kumar, Ch. Kiran Kumar, P. Raja Abhilash

DOI: 10.5958/2231-5713.2016.00012.X         Access: Open Access Read More

Author(s): Subhashis Debnath, C Shashank, M. Niranjan Babu, R Suresh Kumar

DOI: 10.5958/2231-5713.2017.00020.4         Access: Open Access Read More

Author(s): P. Sabitha Reddy, S. Sujani, K. Ravindra Reddy

DOI:         Access: Open Access Read More

Author(s): Poonam M. Lalwani, S.D. Barhate, M.M. Bari

DOI: 10.5958/2231-5713.2018.00021.1         Access: Open Access Read More

Author(s): S.C. Shivhare, U.D.Shivhare, Preeti Srivastav, K.G. Malviya

DOI:         Access: Open Access Read More

Author(s): Varsha Gharge, Pravin Pawar

DOI: 10.5958/2231-5713.2018.00005.3         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags