Author(s): Janvi Sanjay Choudhary, Sunila. A. Patil, Sunil. P. Pawar

Email(s): janvichoudhary5454@gmail.com

DOI: 10.52711/2231-5713.2026.00038   

Address: Janvi Sanjay Choudhary, Sunila. A. Patil, Sunil. P. Pawar
P.S.G.V.P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India, 425409.
*Corresponding Author

Published In:   Volume - 16,      Issue - 3,     Year - 2026


ABSTRACT:
Turmeric is a spice that comes from the rhizomes of Curcuma longa, which belongs to the ginger family, Zingiberaceae. Rhizomes are horizontal underground stems that produce shoots and roots. The spice is sometimes called ‘Indian saffron’ because of its bright color. The bright yellow color of turmeric mainly comes from fat-soluble, polyphenolic pigments called curcuminoids. Curcumin is the main curcuminoid in turmeric and is usually seen as its most active component. Other curcuminoids present in turmeric include demethoxycurcumin and bisdemethoxycurcumin. Besides being a spice and colorant, turmeric has been used for medicinal purposes in India for centuries. Recently, studies have shown that curcumin may have anti-inflammatory and anticancer properties, sparking renewed scientific interest in its potential to prevent and treat disease.


Cite this article:
Janvi Sanjay Choudhary, Sunila. A. Patil, Sunil. P. Pawar. A Systematic Review of Phytochemistry, Pharmacological Activities and Therapeutic Applications of Curcuma Longa. Asian Journal of Pharmacy and Technology. 2026; 16(3):266-0. doi: 10.52711/2231-5713.2026.00038

Cite(Electronic):
Janvi Sanjay Choudhary, Sunila. A. Patil, Sunil. P. Pawar. A Systematic Review of Phytochemistry, Pharmacological Activities and Therapeutic Applications of Curcuma Longa. Asian Journal of Pharmacy and Technology. 2026; 16(3):266-0. doi: 10.52711/2231-5713.2026.00038   Available on: https://ajptonline.com/AbstractView.aspx?PID=2026-16-3-8


REFERENCES:
1.    Panpatil VV, Tattari S, Kota N, Nimgulkar C and Polasa K. In-vitro evaluation on antioxidant and antimicrobial activity of spice extracts of ginger, turmeric and garlic. Journal of Pharmacognosy and Phytochemistry. 2013; 2(3): 143-148. 
2.    Pawar H, Karde M, Mundle N, Jadhav P and Mehra K. Phytochemical evaluation and curcumin content determination of turmeric rhizomes collected from Bhandara District of Maharashtra (India). Med. Chem. 2014; 4(8): 588-591. 
3.    Aggarwal BB, Kumar A and Bharti AC: Anticancer potential of curcumin. preclinical and clinical studies. Anticancer Research. 2003; 23(1/A): 363-398.
4.    Majeed M, Murray F, Badmaev V. Turmeric and the Healing Curcuminoids, McGraw-Hill Education; 1999. p.122-127.
5.    Bhutya R,. Ayurvedic medicinal plants of india, Vol. 1, Scientific Publishers, 2011.p.25-27
6.    Salehi B, Zucca P, Sharifi-Rad M, Pezzani R. Phytotherapeutics in cancer invasion and metastasis. Phytotherapy Research. 2018; 32(8): 1425-1449. 
7.    Kharat M, Du Z, Zhang G and McClements DJ. Physical and chemical stability of curcumin in aqueous solutions and emulsions: Impact of pH, temperature and molecular environment. Journal of Agricultural and Food Chemistry. 2017; 65(8): 1525-1532. 
8.    Hewlings SJ and Kalman DS. Curcumin: a review of its effects on human health. Foods. 2017; 6(10): 92. 
9.    Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M and Sahebkar A. Antioxidant and anti-inflammatory effects of Curcumin oid piperine combination in subjects with metabolic syndrome: a randomized controlled trial and an updated meta analysis. Clinical Nutrition. 2015; 34(6): 1101-1108. 
10.    Prasad S, Aggarwal B. Turmeric, The Golden Spice: From Traditional Medicine to Modern Medicine. 2011;. p. 13.    
11.    Rheim FA, Ragab AA, Hamdy HED and Hammam FM: Evaluation of DNA damage in-vivo by comet assay and chromosomal aberrations for pyrethroid insecticide and the antimutagenic: Role of curcumin. The Egyptian Journal of Hospital Medicine. 2015; 59: 172-181. 
12.    1Gómez-Estaca J, Balaguer MP, López Carballo G, Gavara R and Hernández Muñoz P. Improving antioxidant and antimicrobial properties of curcumin by means of encapsulation in gelatin through electrohydrodynamic atomization. Food Hydrocolloids. 2017; 70: 313-320. 
13.    Noorafshan A and Ashkani-Esfahani S. A review of therapeutic effects of curcumin. Current Pharmaceutical Design. 2013; 19(11): 2032-2046. 
14.    Prasad S, Tyagi AK and Aggarwal BB. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer research and treatment. Official Journal of Korean Cancer Association. 2014; 46(1): 2. 
15.    Gupta SC, Patchva S and Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS Journal. 2013; 15(1): 195-218. 
16.    Hu S, Maiti P, Ma Q, Zuo X, Jones MR, Cole GM and Frautschy SA. Clinical development of curcumin in neurodegenerative disease. Expert Review of Neuro Therapeutics. 2015; 15(6): 629 637. 
17.    Rungseesantivanon S, Thenchaisri N, Ruangvejvorachai P and Patumraj S. Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complementary and Alternative Medicine. 2010; 10: 57-57
18.    Kocaadam, B., Şanlier, N. Curcumin, An active component of turmeric (Curcuma longa), and its effects on health. Crit. Rev. Food Sci. Nutr. 2017; 57, 2889–2895.
19.    Li S, Chemical Composition and Product Quality Control of Turmeric (Curcuma longa L.). Pharmaceutical Crops. 2011; 5: 28-54. 
20.    Riva A, Franceschi F, Togni S, Eggenhoffner R, Giacomelli L, Health Benefits of Curcumin and Curcumin Phytosome in Bone Density Disorders. JSM Bone Marrow Res. 2017; 1: 77-79. 
21.    Henrotin Y, Priem F, Mobasheri A. Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. SpringerPlus. 2013; 2(56): 13 17. 
22.    Staff T P, PDR for Herbal Medicines, Thomson PDR, 2004. p. 234.
23.    Jaggi Lal. Turmeric, Curcumin and Our Life: A Review. Bulletin of Environment, Pharmacology and Life Sciences. 2012;(17):11-17.  
24.    Roshan Prasad Yadav and Gaur Tarun. Versatility of turmeric: A review the golden spice of life. Journal of Pharmacognosy and Phytochemistry. 2017;6(1):41-46.
25.    Pfeiffer E, Hhle S, Solyom AS and Metzler M. Studies on the stability of turmeric constituents. J Food Enginee. 2003; 56:257-259.
26.    26.Sunghwan Kim, Paul A. Thiessen. Pubchem Open Chemistry Data Base. Nucleic Acids Res. 2016; 4: 44.
27.    Priyadarsini, K.I. The chemistry of curcumin: from extraction to therapeutic agent. Molecules 2014; 19: 20091-20112. 
28.    Fanti F, Conti S, Campani L, Morace G, Dettori G, Polonelli L. Studies on the epidemiology of Aspergillus fumigatus infections in a university hospital. European journal of epidemiology. 1989; 5, 8-14.
29.    Nelson KM, Dahli JL, Bisson, J, Graham J, Pauli GF, Walters, MA. The Essential Medicinal Chemistry of Curcumin. Journal of medicinal chemistry. 2017; 60: 1620 1637 
30.    Kumar D, Basu S, Parija L, Rout D, Manna S, Debata, PR. Curcumin and Ellagic acid synergistically induce ROS generation, International Journal of Research and Review (ijrrjournal.com) Vol.7; Issue: 1; January 2020 284 Surbhi Rathore et.al. Curcumin: A Review for Health Benefits International Journal of Research and Review (ijrrjournal.com) 285 Vol.7; Issue: 1; January 2020 DNA damage. Biomedicine & pharmacotherapy. 2016; 81: 31-37. 
31.    Sharma OP. Antioxidant activity of curcumin and related compounds. Biochemical pharmacology. 1976; 25: 1811-1812. 
32.    Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as "Curecumin": from kitchen to clinic. Biochemical pharmacology. 2008; 75: 787-809. 
33.    Jurenka, JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research Alternative medicine review. a journal of clinical therapeutic. 2009; 14: 141-153. 
34.    Shishodia S, Sethi G, Aggarwal BB. Curcumin: getting back to the roots. Annals of the New York Academy of Sciences. 2005; 10(56): 206-217. 
35.    Priyadarsini, KI. Photophysics, photochemistry and photobiology of curcumin: Studies from organic solutions, bio-mimetics and living cells. J Photoch Photobioc. 2009; 10: 81-95. 
36.    Griesser M, Pistis V, Suzuki T, Tejera N, Pratt DA, Schneider C. Autoxidative and cyclooxygenase-2 catalyzed transformation of the dietary chemopreventive agent curcumin. The Journal of biological chemistry. 2011; 286: 1114-1124 
37.    Tamvakopoulos, C, Dimas K, Sofianos ZD. Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin. Clinical cancer research: an official journal of the American Association for Cancer Research. 2007; 13: 1269-1277. 
38.    Robinson TP, Hubbard RB. Synthesis and biological evaluation of aromatic enones related to curcumin. Bioorganic & medicinalchemistry. 2005; 13: 4007-4013.
39.    Sueth-Santiago V, Moraes JdBB, Sobral Alves ES, Vannier-Santos MA, Freire-de-Lima CG, Castro RN, et al. (2016) The Effectiveness of Natural Diarylheptanoids against Trypanosoma cruzi: Cytotoxicity, Ultrastructural Alterations and Molecular Modeling Studies. PLoS ONE 11(9): e0162926 ; Khanna, M.M. (1999). Turmeric - Nature's precious gift. Current Sci. 76(10): 1351-1356. 
40.    Gupta AP, Khan S, Manzoor MM, Yadav AK, Sharma G, Anand R and Gupta S: Anticancer curcumin: Natural analogues and structure-activity relationship. In Studies in Natural Products Chemistry, Elsevier. 2017; 54: 355-401. 
41.    Dulbecco P and Savarino V: Therapeutic potential of curcumin in digestive diseases. World Journal of Gastroenterology. 2013; 19(48): 9256. 
42.    Maheshwari RK, Singh AK, Gaddipati J and Srimal RC: Multiple biological activities of curcumin: a short review. Life Sciences. 2006; 78(18): 2081-2087. 
43.    Koohpar ZK, Entezari M, Movafagh A and Hashemi M. Anticancer activity of Curcumin on human breast adenocarcinoma: role of Mcl-1 gene. Iranian Journal of Cancer Prevention. 2015; 8(3): 2231. 
44.    SayerA. Yeast Is A Cause of Cancer And Turmeric Can Kill Both. Research Confirms. Research. 2015; 4(2): 339. 
45.    Zhang Q, Li D, Liu Y, Wang H,et al. Potential anticancer activity of curcumin analogs containing sulfone on human cancer cells. Archives of Biological Sciences. 2016; 68(1): 125-133. Surbhi Rathore et.al. Curcumin: A Review for Health Benefits 
46.    Siegel R, Ma J, Zou Z and Jemal A. Cancer statistics. A Cancer Journal For Clinicians. 2014; 64(1): 929.
47.    Hilles AR and Mahmood S. A review on phytochemistry and pharmacological effects of Trigonella foenumgraecum. Advanced Herbal Medicine. 2016; 2(3): 61-67. 
48.    Naik SR, Thakare VN and Patil SR. Protective effect experimentally of induced curcumin on inflammation, hepatotoxicity and cardiotoxicity in rats: evidence of its antioxidant property. Experimental and Toxicologic Pathology. 2011; 63(5): 419-431. 
49.    Kim J, Lee HJ and Lee KW. Naturally occurring phytochemicals for the prevention of Alzheimer’s disease. Journal of Neurochemistry. 2010; 112(6): 1415-1430.
50.    Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: a randomized controlled trial and an updated meta-analysis. Clinical nutrition. 2015; 34: 1101-1108.
51.    Hanahan D, Weinberg RA. Hallmarks of cancer the next generation. Cell. 2011; 144(5): 646 -674. 
52.    Nakano K, VousdenKH, PUMA. A Novel proapoptotic gene, is induced. Molecular cell. 2001; 7(3): 683-694. 
53.    Duvoix A ,Blasius R, Delhalle S, Schnekenburger M, et al. Chemopreventive and therapeutic effects of curcumin. Cancer letters. 2003; 223(2): 181-190. 
54.    Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Curcumin and Cancer: an “old-age” disease with an “age-old” solution. Cancer letters, 2008; 267(1): 133-164. 
55.    Bar-Sela G, Epelbaum R, Schaffer M. Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. Current medicinal chemistry. 2010; 17(3): 190-197. 
56.    Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can Curry kill tumor cells selectively. The AAPS journal. 2009; 11(3): 495-510 
57.    Bayomi SM, El-Kashef HA, El-Ashmawy MB, Nasr MN, El-Sherbeny MA, Abdel Aziz NI, et al. Synthesis and biological evaluation of new curcumin analogues as antioxidant and antitumor agents: Molecular modeling study. European Journal of Medicinal Chemistry. 2015; 101: 584-594. 
58.    Wilken R, Veena MS, Wang MB and Srivatsan ES. Curcumin: A review of anti cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Molecular Cancer 2011; 10(1): 12-17. 
59.    Fiala M. Curcumin and omega-3 fatty acids enhance NK cell-induced apoptosis of pancreatic cancer cells but Curcumin inhibits interferon-γ production: benefits of omega-3 with Curcumin against cancer. Molecules. 2015; 20(2): 3020-3026. 
60.    Attari F, Zahmatkesh M, Aligholi H, Mehr SE, Sharifzadeh M, Gorji A, Mokhtari T, Khaksarian M and Hassanzadeh G: Curcumin as a double-edged sword for stem cells: dose, time and cell type-specific responses to Curcumin. DARU Journal of Pharmaceutical Sciences. 2015; 23(1): 33.
61.    61.Tsekova PB, Spasova MG, Manolova NE, Markova ND and Rashkov IB. Electrospun Curcumin -loaded cellulose acetate/polyvinylpyrrolidone fibrous materials with complex architecture and antibacterial activity. Materials Science and Engineering. 2017; 73: 206-214. 
62.    No DS, Algburi A, Huynh P, Moret A, Ringard M, Comito N, Drider D, Takhistov P and Chikindas ML. Antimicrobial efficacy of curcumin nanoparticles against Listeria monocytogenes is mediated by surface charge. Journal of Food Safety. 2017; 3(7) 21-27.
63.    Yang XX, Li CM, Li YF, Wang J and Huang CZ. Synergistic antiviral effect of curcumin functionalized graphene oxide against respiratory syncytial virus infection. Nanoscale. 2017; 9(41): 16086-16092. 66. Buckley D, Fraser A, Huang G and Jiang X. Recovery Optimization and Survival of the Human Norovirus Surrogates Feline Calicivirus and Murine Norovirus on Carpet. Applied and Environmental Microbiology. 2017; 83(22): e01336-17. 
64.    Buckley D, Fraser A, Huang G and Jiang X. Recovery Optimization and Survival of the Human Norovirus Surrogates Feline Calicivirus and Murine Norovirus on Carpet. Applied and Environmental Microbiology. 2017; 83(22): e01336-17. 
65.    Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S and Aggarwal BB. Curcumin the golden nutraceutical: multitargeting for multiple chronic diseases. British Journal of Pharmacology. 2017; 174(11): 1325-1348.
66.    Kim J, Lee HJ and Lee KW. Naturally occurring phytochemicals for the prevention of alzheimer’s disease. Journal of Neurochemistry. 2010; 112(6): 1415-1430.
67.    Ghosh N, Ghosh R and Mandal SC. Antioxidant protection a promising therapeutic intervention in neurodegenerative disease. Free Radical Research. 2011; 45(8): 888-905.
68.    68.Hussain Z, Thu HE, Ng SF, et al. Nanoencapsulation an Efficient and promising approach to maximize wound healing efficacy of curcumin:A review of new trends and state-of-the-art. Colloids and Surfae B. Biointerfaces. 2017; 150: 223 241. 
69.    Jackson JK, Higo T, Hunter WL and Burt HM. The antioxidants Curcumin and quercetin inhibit inflammatory processes associated with arthritis. Inflammation Research. 2006; 55(4): 168-175.
70.    Dutta B. Study of secondary metabolite constituents and curcumin contents of six different species of genus Curcuma. Journal of Medicinal Plants Studies. 2015;3(5):116-119.
71.    Patil SS, Bhasarkar S, Rathod VK. Extraction of curcuminoids from Curcuma longa: Comparative study between batch extraction and novel three phase partitioning. Preparative Biotechnology. Biochemistry and 2019;49(4):407-418.
72.    Sahne F, Mohammadi M, Najafpour GD, Moghadamnia AA. Extraction of bioactive compound curcumin from turmeric (Curcuma longa l.) Via different routes: a comparative study. Pak. J. Biotechnol. 2016;13(3):173 180.
73.    Nurhadi B, Saputra RA, Setiawati TA, Husein SN, Faressi FR, Utari CD, et al. Comparison of Curcuma domestica and Curcuma xanthorrhiza oleoresins extracted using maceration, Soxhlet, and ultrasound assisted extraction (UAE). IOP Conference Series: Earth and Environmental Science. 2020; 443(1): 012074.

Recomonded Articles:

Author(s): A. K. Meena, Jyoti Meena, Ankush Jadhav, M. M. Padhi

DOI:         Access: Open Access Read More

Author(s): Chaudhari R. D, Girase P. R, Suryawanshi H. P, Pawar S. P

DOI: 10.5958/2231-5713.2018.00025.9         Access: Open Access Read More

Author(s): Ruchika Sharma, M. S. Ashawat, C. P. S Verma, Neha Kumari

DOI: 10.5958/2231-5713.2020.00039.2         Access: Open Access Read More

Author(s): Rutuja Saurabh Shah

DOI: 10.52711/2231-5713.2021.00035         Access: Open Access Read More

Author(s): Swati Siddheshwar Londhe, Mangesh Gautam Bhosale, Amol Arun Joshi

DOI: 10.5958/2231-5713.2020.00041.0         Access: Open Access Read More

Author(s): Sushil D. Patil, Mukul J. Gupta, Kaustubh S. Kote, Mr. Rajendran R

DOI: 10.5958/2231-5713.2019.00039.4         Access: Open Access Read More

Author(s): Basavaraj, Someswara Rao B, S.V Kulkarni, Pramod Patil , Chetan Surpur

DOI:         Access: Open Access Read More

Author(s): Debarshi Kar Mahapatra , Ruchi S. Shivhare , Vinod G. Ugale

DOI: 10.5958/2231-5713.2018.00008.9         Access: Open Access Read More

Author(s): Anita S. Godase, Nayana V. Pimpodkar, Yogita R. Indalkar

DOI: 10.5958/2231-5713.2015.00030.6         Access: Open Access Read More

Author(s): S. Rawat, Akhilesh Gupta

DOI:         Access: Open Access Read More

Author(s): Prajapati Krishna V., Jain Vinit C., Prajapati Neelam

DOI: 10.5958/2231-5713.2016.00007.6         Access: Open Access Read More

Author(s): Brijesh Kumar Saroj, Shreyash Tripathi, Mohd Yaqub Khan

DOI: 10.5958/2231-5713.2018.00034.X         Access: Open Access Read More

Author(s): Ajinkya P. Lonare, Disha S. Nipurte, Aditya P. Lonare

DOI: 10.52711/2231-5713.2024.00004         Access: Open Access Read More

Author(s): Sujata S. Sawant, Sangram S. Patil, Hemant S. Kandle, Manohar D. Kengar, Ganesh B. Vambhurkar, Mangesh A. Bhutkar

DOI: 10.5958/2231-5713.2019.00029.1         Access: Open Access Read More

Author(s): Vani Mamillapalli, Ratna Harika Chapala, Tejaswi Komal Sai Sareddu, Latha Sri Kondaveeti, Santhi Pattipati, Padmalatha Khantamneni

DOI: 10.5958/2231-5713.2020.00025.2         Access: Open Access Read More

Author(s): Siddhi Prakash Fogueri, Sanyuja Satish Nikam, Mukund Vivek Gawade, Harshada Suresh Shetye, Akshata Anil Thakur, Tanvi Ganesh Valanju, Vijay Arjun Jagtap

DOI: 10.5958/2231-5713.2020.00037.9         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Journal Policies & Information




Recent Articles




Tags