Author(s):
Amolkumar A. Kempwade, Renu S. Hambar, Shital Khavare, Neha B. Mangale, Akshay D. Patil, Niranjan M. Nalawade
Email(s):
kempwadeamol@rediffmail.com
DOI:
10.52711/2231-5713.2026.00034 
Address:
Amolkumar A. Kempwade*, Renu S. Hambar, Shital Khavare, Neha B. Mangale, Akshay D. Patil, Niranjan M. Nalawade
Department of Pharmaceutics, KLE’s College of Pharmacy, Nipani 591237, Karnataka, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2026
ABSTRACT:
Ondansetron hydrochloride is a selective 5-HT3 receptor antagonist used to prevent nausea and vomiting, but it has low solubility and moderate oral bioavailability (60%) with a half-life of 4–5 hours. The study aimed to improve its solubility by preparing co-crystals and solid dispersions and delivering the drug via the buccal route to bypass gastrointestinal exposure and enhance patient compliance. Preformulation studies confirmed the purity of the drug. Co-crystals were prepared using a 1:1 molar ratio with selected co-formers, while solid dispersions were made using polymers such as PVP K-30, PEG-4000, and Eudragit RS-100. Buccal patches of the optimized co-crystal were developed using chitosan and PVP by solvent casting and evaluated for physicochemical properties and in vitro drug release. Tartaric acid-based co-crystals showed a 13-fold increase in solubility, and the buccal patch exhibited 95.58% drug release in 10 minutes compared to 45.34% for the plain drug. The study concluded that co-crystallization effectively enhances solubility and the buccal route is a promising alternative for ondansetron delivery.
Cite this article:
Amolkumar A. Kempwade, Renu S. Hambar, Shital Khavare, Neha B. Mangale, Akshay D. Patil, Niranjan M. Nalawade. Explore various Solubility Enhancement Techniques to Enhance the Solubility of Ondansetron Hydrochloride. Asian Journal of Pharmacy and Technology. 2026; 16(3):241-5. doi: 10.52711/2231-5713.2026.00034
Cite(Electronic):
Amolkumar A. Kempwade, Renu S. Hambar, Shital Khavare, Neha B. Mangale, Akshay D. Patil, Niranjan M. Nalawade. Explore various Solubility Enhancement Techniques to Enhance the Solubility of Ondansetron Hydrochloride. Asian Journal of Pharmacy and Technology. 2026; 16(3):241-5. doi: 10.52711/2231-5713.2026.00034 Available on: https://ajptonline.com/AbstractView.aspx?PID=2026-16-3-4
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