Author(s): Ankita R. Koshti, Sachin B. Jadhav, M. M. Bari, Dr. S. D. Barhate

Email(s): ankitakoshti59@gmail.com

DOI: 10.5958/2231-5713.2019.00036.9   

Address: Ankita R. Koshti*, Sachin B. Jadhav, M. M. Bari, Dr. S. D. Barhate
Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner-424206 Dist. Jalgaon, Maharashtra
*Corresponding Author

Published In:   Volume - 9,      Issue - 3,     Year - 2019


ABSTRACT:
The purpose of the study was to mask the bitter taste of fexofenadine HCl by using pH sensitive polymer, Eudragit E100. The taste masking of fexofenadine HCl was achieved by preparing taste masked granules using Eudragit E100 by wet granulation method. These granules were then formulated into ODTs using superdisintegrant addition technique. Central composite design was applied as an optimization technique. FTIR and DSC studies indicated drug and excipients were compatible with each other. The prepared ODTs were evaluated for precompression and post compression parameters. The optimized batch FFH3 were passes all the precompression and post compression parameters and it was given as best by the CCD. The disintegration time and % drug released was found to be 23 seconds and 99.40% within 30 min respectively. As Eudragit E100 is soluble at pH below 5, 0.001N HCl stimulating the gastric fluid was chosen as the dissolution medium. It was concluded that ODTs of fexofenadine HCl were successfully prepared by taste masking method using pH sensitive polymer Eudragit E100 and croscarmellose sodium as superdisintegrant using central composite design. As per CDER guideline it shows disintegration time within 5-30 seconds.


Cite this article:
Ankita R. Koshti, Sachin B. Jadhav, M. M. Bari, Dr. S. D. Barhate. Formulation optimization and Evaluation of Orodispersible Tablet of taste masked Fexofenadine hydrochloride. Asian J. Pharm. Tech. 2019; 9(3):212-219. doi: 10.5958/2231-5713.2019.00036.9


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DOI: 10.5958/2231–5713 


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