Rajeshree Panigrahi, K.A. Chowdary, Gitanjali Mishra, Manas Bhowmik, Saiprasanna Behera
Rajeshree Panigrahi1*, K.A. Chowdary2, Gitanjali Mishra3, Manas Bhowmik4, Saiprasanna Behera1
1Royal College of Pharmacy and Health Sciences - Berhampur
2St. Ann’s college of Pharmacy, Cantonment- Vizianagram
3Berhampur University- Berhampur
4Himalayan Institute of Pharmacy, Sikkim
Volume - 2,
Issue - 3,
Year - 2012
Fast dissolving tablets of Lisinopril were designed using combination of synthetic superdisintegrants like croscarmellose sodium, crospovidone and sodium starch glycolate in a ratio of 5:10 and 10:5 respectively by direct compression method. The blends of all formulations were evaluated for various pre-formulation factors. Tablets were evaluated for weight variation, hardness, disintegration time, drug content, friability and in vitro dissolution. The formulation of Lisinopril containing 10% crospovidone and 5% croscarmellose showed disintegration time of 145±0.502 secs respectively with 99% drug release within 30 mins. The results showed that super disintegrants used in combinations shows better disintegrating property. The FTIR spectra showed no interactions among them.
Cite this article:
Rajeshree Panigrahi, K.A. Chowdary, Gitanjali Mishra, Manas Bhowmik, Saiprasanna Behera. Formulation of fast dissolving tablets of Lisinopril using combination of synthetic superdisintegrants . Asian J. Pharm. Tech. 2(3): July-Sept. 2012; Page 94-98.