Author(s):
Geetanjali Sahu, Pooja Yadav, Daulal, Sandeep Sahu, Bhavesh Shriwas
Email(s):
geetanjali.sahu574@gmail.com
DOI:
10.52711/2231-5713.2026.00047 
Address:
Geetanjali Sahu1, Pooja Yadav2, Daulal2, Sandeep Sahu2, Bhavesh Shriwas2
1Assistant Professor, School of Pharmacy, Chouksey Engineering College, Lalkhadan, Bilaspur, Chhattisgarh, Pincode 495004, India.
2School of Pharmacy, Chouksey Engineering College, Lalkhadan, Bilaspur, Chhattisgarh, Pincode 495004, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2026
ABSTRACT:
Respiratory disorders such as allergic rhinitis, sinusitis, and upper airway inflammation require therapeutic approaches that provide rapid onset of action and improved patient compliance. Herbal actives delivered through nasal in-situ gelling systems offer advantages such as prolonged residence time, sustained release, and enhanced mucosal absorption. Ocimum sanctum (Tulsi) possesses potent anti-inflammatory, antimicrobial, immunomodulatory, and antioxidant properties, making it a promising candidate for nasal formulations. The present study aimed to develop and characterize a thermosensitive nasal in-situ gel of Ocimum sanctum extract using Poloxamer 407 and HPMC as gelling and viscosity-modifying agents. A hydroalcoholic extraction method was optimized to obtain a phytochemically rich Tulsi extract. The formulated gels were evaluated for pH, clarity, viscosity, gelation temperature, drug content, in-vitro gelation, spreadability, rheology, in-vitro drug release, antimicrobial activity, and stability. Results indicated the successful development of a stable nasal in-situ gel with desirable physicochemical and release characteristics suitable for respiratory disorders.
Cite this article:
Geetanjali Sahu, Pooja Yadav, Daulal, Sandeep Sahu, Bhavesh Shriwas. Preparation of Nasal In-situ gel of Ocimum sanctum for Respiratory Disorders. Asian Journal of Pharmacy and Technology. 2026; 16(4):339-3. doi: 10.52711/2231-5713.2026.00047
Cite(Electronic):
Geetanjali Sahu, Pooja Yadav, Daulal, Sandeep Sahu, Bhavesh Shriwas. Preparation of Nasal In-situ gel of Ocimum sanctum for Respiratory Disorders. Asian Journal of Pharmacy and Technology. 2026; 16(4):339-3. doi: 10.52711/2231-5713.2026.00047 Available on: https://ajptonline.com/AbstractView.aspx?PID=2026-16-4-2
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