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Asian Journal of Pharmacy and Technology
ISSN: 2231-5713(Online), 2231-5705(Print)
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Dissolution enhancement of Telmisartan by spray drying technique
Girishchandra R. Mandake
Shital S. Shinde
Omkar A. Patil
Manojkumar M. Nitalikar
Girishchandra R. Mandake*, Shital S. Shinde, Omkar A. Patil, Manojkumar M. Nitalikar
Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra India- 415404
The purpose of this research work was to improve the solubility and therefore the rate of dissolution of Telmisartan using spray drying technique. Microspheres of Telmisartan were prepared by using various proportion of drug: PVP-K30 ratios (1:1 to 1:4).The prepared microspheres was subjected to in-vitro dissolution, FT-IR spectroscopy, XRD, and SEM studies. Present investigation describes preparation of microspheres by spray drying technique and the microspheres were found to be discrete, spherical with free flowing properties. The results indicated that formulation containing drug: PVP-K30 ratio of 1:4, prepared by spray drying technique showed the cumulative release of 96.36% in phosphate buffer 7.5. Hence, it can be concluded that the microspheres prepared by spray drying technique have potential to enhance the solubility and dissolution rate of Telmisartan.
Telmisartan, Microspheres, In-vitro drug release, SEM, XRD.
Girishchandra R. Mandake, Shital S. Shinde, Omkar A. Patil, Manojkumar M. Nitalikar. Dissolution enhancement of Telmisartan by spray drying technique. Asian J. Pharm. Tech. 2018; 8 (4):264-269.
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