Author(s): Liji Jacob, Manju Salim S, Jilby Saju

Email(s): lijivjacob@gmail.com

DOI: 10.52711/2231-5713.2022.00016   

Address: Liji Jacob, Manju Salim S, Jilby Saju
Department of Pharmaceutics, Al-Azhar College of Pharmacy, Perumpillychira - 685605, Thodupuzha, Kerala, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2022


ABSTRACT:
Selegiline is an antiparkinsonian drug. It is a MAO-B enzyme inhibitor. It undergoes hepatic first pass metabolism and it result in 10% bioavailability on oral administration. So it was designed to formulate transdermal patches of Selegiline HCl for enhancing the bioavailability and patient compliance. Different formulation were prepared by different grades and varying concentration of polymer by solvent casting method. PG was used as permeation enhancer. The films were subjected to evaluation parameters like weight variation, thickness, moisture content, tensile strength, folding endurance, drug content and in-vitro drug release.


Cite this article:
Liji Jacob, Manju Salim S, Jilby Saju. Formulation and Evaluation of Transdermal Patches of Selegiline. Asian Journal of Pharmacy and Technology. 2022; 12(2):96-0. doi: 10.52711/2231-5713.2022.00016

Cite(Electronic):
Liji Jacob, Manju Salim S, Jilby Saju. Formulation and Evaluation of Transdermal Patches of Selegiline. Asian Journal of Pharmacy and Technology. 2022; 12(2):96-0. doi: 10.52711/2231-5713.2022.00016   Available on: https://ajptonline.com/AbstractView.aspx?PID=2022-12-2-2


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