Author(s): Nitin A. Gaikwad, Abhishek S. Pujari, Indrajeet V. Mane, Ganesh B. Vambhurkar, Pravin P. Honmane

Email(s): nitingaikwadrcp@gmail.com

DOI: 10.5958/2231-5713.2019.00017.5   

Address: Nitin A. Gaikwad*, Abhishek S. Pujari , Indrajeet V. Mane, Ganesh B. Vambhurkar, Pravin P. Honmane
Rajarambapu College of Pharmacy, Kasegaon, Dist – Sangli, Maharashtra, INDIA – 415404
*Corresponding Author

Published In:   Volume - 9,      Issue - 2,     Year - 2019


ABSTRACT:
The aim of the present study was to investigate the effect of Soluplus on the solubility of atorvastatin and to develop a nanocrystals formulation that can improve the oral bioavailability of atorvastatin. We demonstrated that Soluplus increases the aqueous solubility of atorvastatin. Several nanocrystals formulations of atorvastatin with Soluplus were prepared at using drug: carrier ratio of 1:1, 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5, 1:1.6, 1:1.7, 1:1.8, 1:1.9 and 1:2 by anti-solvent precipitation. Physicochemical analysis demonstrated that atorvastatin is crystalline in each nanocrystals and the 1:1 drug: carrier ratio provided the highest degree of sustained atorvastatin super saturation. The prepared nanocrystals were characterized by Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimeter, X-ray Diffraction Study, Zeta potential Nuclear magnetic resonance and Scanning Electron Microscopy. Solubility and dissolution study was performed to check the enhanced properties of nanocrystals of atorvastatin. It was observed that, nanocrystals tablet containing nanocrystals exhibited significantly faster solubility and drug dissolution as compared with conventional and marketed tablet of a drug. Amongst all nanocrystals formulations with drug polymer ratio 1:1 shows highest solubility that is 2.5027±0.77 as compared to pure drug 0.4918±0.51 mg/ml. This increase solubility and dissolution due to increased surface area and characteristics of nanocrystals and soluplus.


Cite this article:
Nitin A. Gaikwad, Abhishek S. Pujari , Indrajeet V. Mane, Ganesh B. Vambhurkar, Pravin P. Honmane. Formulation and Characterization of Atorvastatin Nanocystal Tablet. Asian J. Pharm. Tech. 2019; 9(2):99-106. doi: 10.5958/2231-5713.2019.00017.5

Cite(Electronic):
Nitin A. Gaikwad, Abhishek S. Pujari , Indrajeet V. Mane, Ganesh B. Vambhurkar, Pravin P. Honmane. Formulation and Characterization of Atorvastatin Nanocystal Tablet. Asian J. Pharm. Tech. 2019; 9(2):99-106. doi: 10.5958/2231-5713.2019.00017.5   Available on: https://ajptonline.com/AbstractView.aspx?PID=2019-9-2-7


Recomonded Articles:

Author(s): Manohar D. Kengar, Rohit S. Howal, Dattatray B. Aundhakar, Amit V. Nikam, Priyajit S. Hasabe

DOI: 10.5958/2231-5713.2019.00010.2         Access: Open Access Read More

Author(s): Abhishek K. Sah, Manmohan Singh Jangdey, Sanjay J. Daharwal

DOI:         Access: Open Access Read More

Author(s): Wajid Ahmad, Jaza Quazi, Reshma Khan, Nadeem Ahmad, Nawed Ansari

DOI: 10.52711/2231-5713.2022.00023         Access: Closed Access Read More

Author(s): Yogita. Chowdhary

DOI: 10.5958/2231-5713.2018.00002.8         Access: Open Access Read More

Author(s): Beedha. Saraswathi, Dr. T. Satyanarayana, K. Mounika, G. Swathi , K. Sravika, M. Mohan Krishna

DOI: 10.5958/2231-5713.2018.00004.1         Access: Open Access Read More

Author(s): Kanchan R. Pagar, Sarika V. Khandbahale

DOI: 10.5958/2231-5713.2019.00023.0         Access: Open Access Read More

Author(s): Rutuja Saurabh Shah

DOI: 10.52711/2231-5713.2021.00035         Access: Open Access Read More

Author(s): Sanjay Kshirsagar, Manisha Choudhari, Reshmi Sathyan, Shruti Dhore

DOI: 10.5958/2231-5713.2019.00024.2         Access: Open Access Read More

Author(s): Vishwas R. Potphode, Amol S. Deshmukh, Vijay R. Mahajan

DOI:         Access: Open Access Read More

Author(s): Girishchandra R., Mandake, Shital S. Shinde, Vishal Y. Belaskar, Asha M. Jagtap, Ganesh B. Vambhurkar, Manoj M. Nitalikar

DOI: 10.5958/2231-5713.2018.00033.8         Access: Open Access Read More

Author(s): Vanitha Kondi, Ramesh Alluri

DOI:         Access: Open Access Read More

Author(s): Sarjavalagi Vishal Gopal, Prabhat Kumar Chaurasia, Harshitha Arun Pardhe, Singh Suryansh Santosh, Narayan Sah Sonar

DOI: 10.5958/2231-5713.2020.00046.X         Access: Open Access Read More

Author(s): Basavaraj, Someswara Rao B, S.V Kulkarni, Pramod Patil , Chetan Surpur

DOI:         Access: Open Access Read More

Author(s): K. Vanitha. M. Venkataswamy, Sanam Niharika, Alluri Ramesh

DOI: 10.5958/2231-5713.2018.00011.9         Access: Open Access Read More

Author(s): Jangam Payal R, Thombre Nilima A, Gaikwad Pallavi N

DOI: 10.5958/2231-5713.2017.00027.7         Access: Open Access Read More

Author(s): Arpit Gawshinde, Dinesh kumar Mishra, Neha Kamalpuria, Nadeem Farooqui, Surbhi Choursiya

DOI: 10.52711/2231-5713.2021.00036         Access: Open Access Read More

Author(s): V Jhansipriya Marabathuni, M. Bhavani, M. Lavanya, K. Padmaja, N. Madhavi, P. Babu, Ch. M. M. Prasada Rao

DOI: 10.5958/2231-5713.2017.00022.8         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags