Author(s): Kalyani Gudadhe, Mukund Tawar

Email(s): kalyanigudadhe9@gmail.com

DOI: 10.52711/2231-5713.2022.00019   

Address: Kalyani Gudadhe1*, Mukund Tawar2
1Department of Quality Assurance, P.R. Pote Patil College of Pharmacy, Amravati – 444604.
2Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444604.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2022


ABSTRACT:
A rapid, sensitive and accurate method for Estimation of Anti- Histamine in Tablet Dosage Form by RP-HPLC. Mobile phase was Methanol: 0.1%. Ortho phosphoric acid (80:20% v/v). Flow rate was 0.9ml/min. The detection Wavelength was 227nm. The injection volume was 20µl.The proposed method was validated for selectivity, precision, linearity, and accuracy. All validation parameters were within the acceptable range. Linearity studies for Rupatadine Fumarate were performed (10-60µg/ml). The %RSD for accuracy found to be less than 2%. Assay was found to be 99.17 to 101.65 respectively. The range of 10-60µg /ml was selected for the linearity of a standard Rupatadine Fumarate. The 80%, 100% and 120% levels of recovery study were selected to perform the recovery study. Linearity studies for Rupatadine Fumarate was performed on (10-60µg/ml).


Cite this article:
Kalyani Gudadhe, Mukund Tawar. Development and Validation of New Analytical Method for Estimation of Anti-histamine in Tablet Dosage Form. Asian Journal of Pharmacy and Technology. 2022; 12(2):113-8. doi: 10.52711/2231-5713.2022.00019

Cite(Electronic):
Kalyani Gudadhe, Mukund Tawar. Development and Validation of New Analytical Method for Estimation of Anti-histamine in Tablet Dosage Form. Asian Journal of Pharmacy and Technology. 2022; 12(2):113-8. doi: 10.52711/2231-5713.2022.00019   Available on: https://ajptonline.com/AbstractView.aspx?PID=2022-12-2-5


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