Author(s): P. Swathi, K. Rajeswar Dutt, K. N. V Rao, M. Alagar Raja

Email(s): Email ID Not Available

DOI: 10.5958/2231-5713.2017.00025.3   

Address: P. Swathi*, K. Rajeswar Dutt, K. N. V Rao, M. Alagar Raja
Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana.
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2017


ABSTRACT:
A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validation of Sofosbuvir, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Hypersil C18 (4.6×150mm, 5µ) column using a mixture of Methanol (100% v/v) as the mobile phase at a flow rate of 1.0 mL/min, the detection was carried out at 265 nm. The retention time of the Sofosbuvir was 3.515 ±0.02min. The method produce linear responses in the concentration range of 20-100µg/mL of Sofosbuvir. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.


Cite this article:
P. Swathi, K. Rajeswar Dutt, K. N. V Rao, M. Alagar Raja. RP-HPLC Method Development and Validation for Estimation of Sofosbuvir in Pure and Tablet Dosage Form. Asian J. Pharm. Tech. 2017; 7 (3): 153-156. doi: 10.5958/2231-5713.2017.00025.3


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DOI: 10.5958/2231–5713 


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