Author(s): Vaishnavi Inde, Mahesh Kadare, Vinod Matole, Doke Patil, Amar Anil, Harshada Patil, Sneha Kashid, Kajal wani

Email(s): Email ID Not Available

DOI: 10.52711/2231-5713.2024.00046   

Address: Vaishnavi Inde1*, Mahesh Kadare1, Vinod Matole1, Doke Patil2, Amar Anil2, Harshada Patil3, Sneha Kashid4, Kajal wani4
1Shivai Charitable Trust’s College of Pharmacy, Koregaonwadi, Omerga.
2SVSPM’s Arya college of Pharmacy.
3MSS's College of Pharmacy, Medha.
4Poona College of Pharmacy, BVDU.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2024


ABSTRACT:
Transdermal Drug Delivery (TDD) TDD is a painless method of delivering drugs systemically by applying a drug formulation onto intact and healthy skin. Ethosomes are soft malleable vesicles composed mainly of phospholipids, ethanol (relatively high concentration) and water. In vitro and in vivo skin permeation experiments have shown that ethosomal formulations can improve the penetration of both hydrophobic and hydrophilic compounds when compared to traditional liposomes. Cold method and hot method are the two types of method of preparation of ethosomes. In comparison to traditional liposomes, antigen-loaded ethosomes for transcutaneous immunization against Hepatitis B were synthesized and described, demonstrating better entrapment effectiveness, appropriate size range, and a unilamellar, spherical shape.As a topical medium (gel), ethosomes and liposomes of azelaic acid (an anti-keratinizing agent used in the treatment of acne) were created, and the results showed that ETHOS 40 might be responsible for a larger azelaic acid concentration than ETHOS 20 and liposomes.


Cite this article:
Vaishnavi Inde, Mahesh Kadare, Vinod Matole, Doke Patil, Amar Anil, Harshada Patil, Sneha Kashid, Kajal wani. Need of ethosomes as a transdermal drug delivery system. Asian Journal of Pharmacy and Technology. 2024; 14(3):286-8. doi: 10.52711/2231-5713.2024.00046

Cite(Electronic):
Vaishnavi Inde, Mahesh Kadare, Vinod Matole, Doke Patil, Amar Anil, Harshada Patil, Sneha Kashid, Kajal wani. Need of ethosomes as a transdermal drug delivery system. Asian Journal of Pharmacy and Technology. 2024; 14(3):286-8. doi: 10.52711/2231-5713.2024.00046   Available on: https://ajptonline.com/AbstractView.aspx?PID=2024-14-3-15


REFERENCES:
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2.    Anuradha Patel, R.K. Sharma, Mahesh Trivedi, Shivaprakash, Anjana Panicker. Ethosomes: A Novel Tool for Transdermal Drug Delivery. Research J. Pharm. And Tech. 2013; 6(8): 838-841.
3.    Touitou, E.; Godin, B.; Dayan, N.; Weiss, C.; Piliponsky, A.; Levi-Schaffer, F. Intracellular delivery mediated by an ethosomal carrier. Biomaterials. 2001; 22: 3053-3059
4.    Kirjavainen M, Urtti A, Jaaskelainen I, Suhonen TM, Paronen P, Valjakka-Koskela R, Kiesvaara J, Monkkonen J. Interaction of liposomes with human skin in vitro – the influence of lipid composition and structure. Biochim Biophys Acta. 1996; 1304: 179–189.
5.    Godin B, Tauitou Elka. Vesicular carrier for transdermal drug delivery system-ethosomes. Current Drug Delivery. 2005; 2: 269‐275.
6.    Hadgraft J, Guy R. Transdermal Drug Delivery, Developmental Issues and Research Initiatives. New York: Marcel Dekker 1989.
7.    Koli, J.R. and S. Lin. Development of anti oxidant ethosomes for topical delivery utilizing the synergistic properties of Vit A palmitate, Vit E and Vit C., AAPS. Pharm. Sci. Tec., 2009; 11: 1-8.
8.    Touitou, E. Composition of applying active substance to or through the skin.US Patent, 1998; 5: 540-934.
9.    Verma, D.D. and A.  Fahr. Synergistic penetration of ethanol and phospholipids on the topical delivery of cyclosporine. J. Control Release. 2004; 97: 55-66.
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