Author(s): Chahat Manish Patel, Kantilal. B. Narkhede, Anuradha Prajapati, Sachin.B. Narkhede, Shailesh Luhar

Email(s): chahatpatel832@gmail.com

DOI: 10.52711/2231-5713.2025.00008   

Address: Chahat Manish Patel1, Kantilal. B. Narkhede2, Anuradha Prajapati2, Sachin.B. Narkhede2, Shailesh Luhar2
1Department of Pharmaceutics, Smt. BNB Swaminarayan Pharmacy College, Gujarat Technological University, Salvav, Vapi, Gujarat, India, 396191.
2Smt. B.N.B Swaminarayan Pharmacy College, Salvav - Vapi, Gujarat.
*Corresponding Author

Published In:   Volume - 15,      Issue - 1,     Year - 2025


ABSTRACT:
Electrospun nanofibers are gaining prominence in the field of wound healing due to their unique structural and functional properties, which closely mimic the extracellular matrix (ECM). This article provides a comprehensive overview of the preparation methods, applications, and challenges associated with electrospun nanofibers in wound care. The review begins by outlining the complex stages of wound healing and emphasizing the need for advanced materials. It details method of preparation of nanofibers from diverse natural and synthetic polymers, enhancing their biocompatibility and mechanical strength. The article highlights recent advancements in the incorporation of bioactive agents, such as antimicrobial compounds and growth factors, into electrospun scaffolds to promote healing. These multifunctional dressings not only facilitate moisture retention but also enable localized drug delivery, thereby reducing systemic side effects. Despite their potential, challenges remain in standardizing production processes and ensuring scalability for clinical applications. The review concludes by discussing future directions for research, focusing on optimizing electrospun nanofibers for specific wound types and improving their therapeutic efficacy. Overall, electrospun nanofibers represent a promising frontier in wound healing technology, with the potential to significantly enhance patient outcomes


Cite this article:
Chahat Manish Patel, Kantilal. B. Narkhede, Anuradha Prajapati, Sachin.B. Narkhede, Shailesh Luhar. A Rising Emerge of Electrospun Nanofibers: Wound Healing, Preparation, Applications and Challenges. Asian Journal of Pharmacy and Technology. 2025; 15(1):48-0. doi: 10.52711/2231-5713.2025.00008

Cite(Electronic):
Chahat Manish Patel, Kantilal. B. Narkhede, Anuradha Prajapati, Sachin.B. Narkhede, Shailesh Luhar. A Rising Emerge of Electrospun Nanofibers: Wound Healing, Preparation, Applications and Challenges. Asian Journal of Pharmacy and Technology. 2025; 15(1):48-0. doi: 10.52711/2231-5713.2025.00008   Available on: https://ajptonline.com/AbstractView.aspx?PID=2025-15-1-8


REFERENCES:
1.    Alshahrani A, Alharbi F, Alzahrani A, Alzahrani S, Alshammari F, Alshahrani A, et al. Electrospun Polymer Nanofibers: Processing, Properties, and Applications. Polymers. 2022; 14(20): 4456. doi:10.3390/polym14204456. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823865/
2.    Zhang Y, Zhang Y, Zhang Y, Xu Y, Wang C, Zhang Y. Smart Electrospun Nanofibers for Controlled Drug Release: Recent Advances and New Perspectives. Polymers. 2017;9(10):549. doi:10.3390/polym9100549. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492677/.
3.    Chen S, Liu B, Carlson MA, Gombart AF, Reilly DA, Xie J. Recent advances in electrospun nanofibers for wound healing. J Biomed Nanotechnol. 2019; 15(5): 1013-1025. doi:10.1166/jbn.2019.2848. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661929/.
4.    Vundrala SR, Tian Y, Zhang C, Ye Z, Roy K, Chinnappan A, Ramakrishna S, Liu W, Ghosh R. A Review on Electrospun Nanofibers Based Advanced Applications: From Health Care to Energy Devices. Polymers. 2021; 13(21): 3678. doi:10.3390/polym13213678. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587893/.
5.    Zhang Y, Zhang Y, Wang H, Zhang Y, Wang J. Machine Learning-Assisted Optimization of Electrospun Nanofibers: Challenges and Advances. J Mater Sci. 2024;59(1):123-145. doi:10.1007/s10853-024-09994-7. Available from: https://link.springer.com/article/10.1007/s10853-024-09994-7.
6.    Haider A, Haider S, Kang I-K. A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology. Chem Eng Trans. 2018;70: 187-192. doi: 10.1016/j.cet.2015.03.3275. Available from: https://www.sciencedirect.com/science/article/pii/S1878535215003275.
7.    Liu W, Thomopoulos S, Xia Y. Electrospun Nanofibers for Regenerative Medicine. Adv Healthc Mater. 2011;1(1):10-25. doi:10.1002/adhm.201100021.
8.    Vaseashta A, Bölgen N, editors. Electrospun Nanofibers: Principles, Technology and Novel Applications. Cham: Springer; 2022. Available from: https://doi.org/10.1007/978-3-030-99958-2.
9.    Zhang Y, Wang H, Wang J, editors. Introduction to Electrospun Nanofibers. 1st ed. Singapore: Springer; 2015.
10.    Zhang Y, Wang H, Wang J, editors. Introduction to Electrospun Nanofibers. 1st ed. Singapore: Springer; 2017. Available from: https://books.google.co.in/books?hl=en&lr=&id=1MBgDQAAQBAJ&oi=fnd&pg=PR5&dq=introduction+to+electrospun+nanofibers&ots=U3dVa48Bxc&sig=M3mNeB7j_pqn9TGOufRxxtEz6gg&redir_esc=y.
11.    Nalbandian MJ, Kim S, Gonzalez-Ribot HE, Myung NV, Cwiertny DM. Recent advances and remaining barriers to the development of electrospun nanofiber and nanofiber composites for point-of-use and point-of-entry water treatment systems. Water Res. 2024; 228:119220. doi: 10.1016/j.watres.2024.119220.
12.    Poornima D Adpekar, Annamalai Rama, Usha Rani, Anup Naha. Electrospun Nanofibres and Their Biomedical Applications. Research Journal of Pharmacy and Technology. 2020;13(11):5569-75.
13.    Ratnaparkhi MP, Andhale RS, Karnawat GR. Nanofibers – A Newer Technology. Research Journal of Pharmacy and Technology. 2021;14(4):2321-7.
14.    Mayuri M. Shitole, Shailesh S. Dugam, Neha D. Desai, Rahul S. Tade, Sopan N. Nangare. Pharmaceutical Applications of Electrospun Nanofibers: A State-of-the-Art Review. Asian Journal of Pharmaceutics. 2020;10(3):187-201.
15.    Nagadev, M. Durga Srinivasa Rao, P. Venkatesh, D. Hepcykalarani, R. Prema. A Review on Transdermal Drug Delivery Systems. Asian Journal of Research in Pharmaceutical Sciences. 2020;10(2):109-14.
16.    S. Gayathri, K. M. Govindaraju. Fabrication and Characterization of Al/ZnO Blended Polyvinylidene Fluoride (PVDF) Membrane via Electrospun Method. Research Journal of Pharmacy and Technology. 2019; 12(2): 787-90.
17.    Keerthic Aswin S, Jothishwar S, Visvavela Chellaih Nayagam P, G. Priya. Scaffolds for Biomolecule Delivery and Controlled Release – A Review. Research Journal of Pharmacy and Technology. 2018; 11(10): 4719-30.
18.    Sidra Choudhary, Sanket Dharashivkar, Chetan Mahajan, Madhuri Gaikwad. Formulation and Evaluation of Nano-fiber-based Transdermal Patch of Cephalexin. Research Journal of Pharmacy and Technology. 2020; 13(6): 2787-91.
19.     Mansi L. Patil, Swati S. Gaikwad, Harshad S. Kapare. A Systematic Review on Antimicrobial Applications of Nanofibres. Research Journal of Pharmacy and Technology. 2024; 17(1): 427-32.
20.    Ananya Choudhury, D. Nagasamy Venkatesh, Jey Kumar P, Mohammed Asheeq PM. Advanced Wound Care with Biopolymers. Research Journal of Pharmacy and Technology. 2023;16(5):2512-0.
21.    Akshit Katnauria, Abhishek, Happy Choudhary, Kapil Kumar Verma. Development and Evaluation of Mucoadhesive Buccal Patch of Losartan Potassium. Asian Journal of Pharmacy and Technology. 2024;14(2):157-62.

Recomonded Articles:

Author(s): Dibyajyoti Saha, Vibhor kumar Jain, Bindu Jain, Roshni Tandey

DOI:         Access: Open Access Read More

Author(s): Abhijit Ray

DOI:         Access: Open Access Read More

Author(s): A. K. Meena, Jyoti Meena, Ankush Jadhav, M. M. Padhi

DOI:         Access: Open Access Read More

Author(s): Kanchan R. Pagar, Sarika V. Khandbahale

DOI: 10.5958/2231-5713.2019.00023.0         Access: Open Access Read More

Author(s): Chaudhari R. D, Girase P. R, Suryawanshi H. P, Pawar S. P

DOI: 10.5958/2231-5713.2018.00025.9         Access: Open Access Read More

Author(s): Wajid Ahmad, Jaza Quazi, Reshma Khan, Nadeem Ahmad, Nawed Ansari

DOI: 10.52711/2231-5713.2022.00023         Access: Open Access Read More

Author(s): Durgesh Gautam, Preetam Palkar, Kiran Maule, Shilpa Singh, Gopika Sawant, Chinmay Kuvalekar, Tushar Rukari, Vijay A. Jagtap

DOI: 10.5958/2231-5713.2020.00028.8         Access: Open Access Read More

Author(s): Sushil D. Patil, Mukul J. Gupta, Kaustubh S. Kote, Mr. Rajendran R

DOI: 10.5958/2231-5713.2019.00039.4         Access: Open Access Read More

Author(s): Dhadde Gurunath S., Mali Hanmant S., Raut Indrayani D., Nitalikar Manoj M., Bhutkar Mangesh A.

DOI: 10.52711/2231-5713.2021.00025         Access: Open Access Read More

Author(s): Pradip D. Dhangar, Tushar N. Sonawane, Azam. Z. Shaikh, Ritik S. Jain

DOI: 10.5958/2231-5713.2020.00047.1         Access: Open Access Read More

Author(s): Ashwini Shelke, Madhavi Shinde, Rajendra Mogal, Rahul Sable, Anil Jadhav

DOI: 10.5958/2231-5713.2018.00016.8         Access: Open Access Read More

Author(s): Sarjavalagi Vishal Gopal, Prabhat Kumar Chaurasia, Harshitha Arun Pardhe, Singh Suryansh Santosh, Narayan Sah Sonar

DOI: 10.5958/2231-5713.2020.00046.X         Access: Open Access Read More

Author(s): Vishwas R. Potphode, Amol S. Deshmukh, Vijay R. Mahajan

DOI:         Access: Open Access Read More

Author(s): Jangam Payal R, Thombre Nilima A, Gaikwad Pallavi N

DOI: 10.5958/2231-5713.2017.00027.7         Access: Open Access Read More

Author(s): G. Baskar, J. Chandhuru, K. Sheraz Fahad, A.S. Praveen

DOI:         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags