Improvement of Solubility and Dissolution Rate of Indomethacin by Solid Dispersion in Polyvinyl Pyrrolidone K30 and Poloxomer 188

Ashok A. Hajare; Prabhakar R. Jadhav

Asian Journal of Pharmacy and Technology

ISSN

2231-5713 (Online)
2231-5705 (Print)

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Improvement of Solubility and Dissolution Rate of Indomethacin by Solid Dispersion in Polyvinyl Pyrrolidone K30 and Poloxomer 188

Author(s): Ashok A. Hajare, Prabhakar R. Jadhav

Email(s): ashok.hajare@bharatividyapeeth.edu , aahajare@rediffmail.com

DOI: Not Available

Address: Ashok A. Hajare* and Prabhakar R. Jadhav
Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy, Kolhapur, M. S., India - 416013
*Corresponding Author

Published In: Volume - 2, Issue - 3, Year - 2012

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ABSTRACT:
The aim of this study was to prepare and characterize solid dispersion (SD) of indomethacin (INDO) with polyvinyl pyrrolidone K30 (PVP) and poloxamer 118 (POLO) for enhancing its dissolution rate and bioavailability. The SDs of INDO was prepared by solvent evaporation method. The SDs was evaluated for practical yield, drug content, saturation solubility and in vitro dissolution study, Scanning electron microscopy (SEM), X-ray powder diffractometry (XRPD) and differential scanning calorimetry (DSC). The dissolution rates in PVP and POLO SDs were much faster than the pure INDO or physical mixtures (PM). The data from the XRPD showed that the drug was crystalline in all PMs. Significant change in melting peak in DSC thermograms of SDs revealed amorphization. SDs showed marked increase in the solubility of INDO with carrier concentration. At the highest ratio of carriers the drug solubility was enhanced about 6-folds and 3-folds for SD in POLO and in PVP, respectively. The dissolution rate was increased with carrier concentration at pH 7.4. XRPD data revealed a remarkable interaction between the INDO and the carrier that enhanced drug dissolution. The 1:10 ratio of POLO was sufficient for conversion of INDO to amorphous form.

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Cite this article:
Ashok A. Hajare, Prabhakar R. Jadhav. Improvement of Solubility and Dissolution Rate of Indomethacin by Solid Dispersion in Polyvinyl Pyrrolidone K30 and Poloxomer 188. Asian J. Pharm. Tech. 2(3): July-Sept. 2012; Page 116-122.

Cite(Electronic):
Ashok A. Hajare, Prabhakar R. Jadhav. Improvement of Solubility and Dissolution Rate of Indomethacin by Solid Dispersion in Polyvinyl Pyrrolidone K30 and Poloxomer 188. Asian J. Pharm. Tech. 2(3): July-Sept. 2012; Page 116-122. Available on: https://ajptonline.com/AbstractView.aspx?PID=2012-2-3-9

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DOI: 10.5958/2231–5713