Author(s): Raut Indrayani D, Gharge Manisha, Dandwde Sonli, Mohite S.K., Magdum C.S.

Email(s): indrayaniraut7363@rediffmail.com

DOI: 10.5958/2231-5713.2017.00008.3   

Address: Raut Indrayani D*, Gharge Manisha, Dandwde Sonli, Mohite S.K., Magdum C.S.
Rajarambapu College of Pharmacy, Kasegaon MS( India)
*Corresponding Author

Published In:   Volume - 7,      Issue - 1,     Year - 2017


ABSTRACT:
In this investigation fast dissolving tablets of perindopril were prepared using different superdisintegrants like sodium starch glycolate and crosspovidone by direct compression method. Fast dissolving drug delivery is fastest, safest, convenient and most economic method of drug delivery having the highest patient compliance and preferred over conventional tablets therefore it is currently the gold standard in the pharmaceutical industry. Formulations were evaluated for precompressional parameters bulk density, tapped density, cars index, angle of repose etc and postcompressional parameters like uniformity of weight, thickness, hardness, friability, drug content, wetting time, water absorption ratio, in vitro disintegration time and in vitro dissolution study. The formulation A1 to A3 contain increasing concentration of Sodium starch glycolate showed the increases dissolution rate of drug release from 92.75 to 98.25 in 15 min, whereas formulation B1 to B3 contain crosspovidone in increasing concentration also increases the drug release from 94.75 to 99.02 in 15 min. The drug release from FDTs increased with increasing concentration of superdisintegrants and was found to be highest with formulations containing Crosspovidone as compared to sodium starch glycolate.


Cite this article:
Raut Indrayani D, Gharge Manisha, Dandwde Sonli, Mohite S.K., Magdum C.S. Formulation and Characterization of fast Dissolving tablets of Perindopril. Asian J. Pharm. Tech. 2017; 7(1): 51-55. doi: 10.5958/2231-5713.2017.00008.3


Recomonded Articles:

Author(s): Hafsa, Asfa, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5713.2017.00001.0         Access: Open Access Read More

Author(s): Juveriya Fatima, Saniya Khan, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5713.2017.00009.5         Access: Open Access Read More

Author(s): Avinash B. Thalkari, Pawan N. Karwa, Chandrakant S. Gawli

DOI: 10.5958/2231-5713.2018.00017.X         Access: Open Access Read More

Author(s): Safa Mohammed Sadiq, Amtul Kareem, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5713.2017.00002.2         Access: Open Access Read More

Author(s): Abhijit Ray

DOI:         Access: Open Access Read More

Author(s): Abhishek K. Sah, Manmohan Singh Jangdey, Sanjay J. Daharwal

DOI:         Access: Open Access Read More

Author(s): Manohar D. Kengar, Rohit S. Howal, Dattatray B. Aundhakar, Amit V. Nikam, Priyajit S. Hasabe

DOI: 10.5958/2231-5713.2019.00010.2         Access: Closed Access Read More

Author(s): Abdul Saleem Mohammad, Swetha Devidi, Nikhat Fatima, Humera Badar, Syeda Saba Sulthana, Mohammad Akthar Sulthana, Nuha Rasheed

DOI:         Access: Open Access Read More

Author(s): Yogita. Chowdhary

DOI: 10.5958/2231-5713.2018.00002.8         Access: Open Access Read More

Author(s): Brijesh Kumar Duvey, Rohit Goyel, Bharat Parashar, Denesh Verma, Hitesh Dhameja, Dharmesh Sharma

DOI:         Access: Open Access Read More

Author(s): Vishwas R. Potphode, Amol S. Deshmukh, Vijay R. Mahajan

DOI:         Access: Open Access Read More

Author(s): P. Swathi, K. Rajeswar Dutt, K. N. V Rao, M. Alagar Raja

DOI: 10.5958/2231-5713.2017.00025.3         Access: Open Access Read More

Author(s): Anju govind, Manjunath B Menden, Ravikumar, Simila1, Mercy, Narayana Swamy VB

DOI: 10.5958/2231-5713.2016.00013.1         Access: Open Access Read More

Author(s): Rana Khan, Aizaz Ahmed Khan, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5713.2017.00012.5         Access: Open Access Read More

Author(s): Nirmala Rangu, B. Chaitanya Kumari, Ganesh Akula, A Jaswanth

DOI: 10.5958/2231-5713.2018.00001.6         Access: Open Access Read More

Author(s): Rohan Patil, Neha Patil, Aniket Patil , S. J. Shid, V.N. Dange, C.S. Magdum, S.K. Mohite

DOI: 10.5958/2231-5713.2016.00026.X         Access: Open Access Read More

Author(s): Neha Srivastava, Seema Thakur, Anchal Bajaj, Nikita Sahi

DOI:         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags